ArticleScientific reports2016
Design and Fabrication of 3D printed Scaffolds with a Mechanical Strength Comparable to Cortical Bone to Repair Large Bone Defects.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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Who cites it
93 citing papers in PubMed.
- Biomimetic Design and Mechanical Properties of Additively Manufactured Titanium Alloy Implant with Gradient Gyroid Structure.Materials (Basel, Switzerland) · 2026Article
- Biochemical and Physicomechanical Cues of Biomaterials Guide Osteogenic Differentiation of Mesenchymal Stem Cells.International journal of molecular sciences · 2026Review
- Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Geometry-Guided Osteogenesis in Bone-on-a-Chip Systems Using Triply Periodic Minimal Surface Scaffolds.Advanced healthcare materials · 2026Article
- Advancing 3D scaffold models for metastatic prostate cancer in bone: Materials, manufacture, and future perspectives.Biomaterials and biosystems · 2025Review
- Exosome-functionalized collagen-coated 3D-printed PCL scaffold for enhanced osteogenic differentiation and bone regeneration: an in vitro and in vivo study.Journal of biological engineering · 2025Article
- Article
- 3D Bioprinting for Custom Bone Grafts in Orthopaedic Trauma: Current Advances and Clinical Translation.Cureus · 2025Review
- Research on 3D-printed scaffolds with microstructure bio-inspired optimization for orbital bone defect repair.Journal of materials science. Materials in medicine · 2025Article
- Novel Nanomaterials for Developing Bone Scaffolds and Tissue Regeneration.Nanomaterials (Basel, Switzerland) · 2025Review
- Fatigue Behavior of the Auxetic Porous Bone Screw Under the Multiaxial Cyclic Loads in Tibiotalocalcaneal Arthrodesis.Annals of biomedical engineering · 2025Article
- 3D-printed gallium-infused scaffolds for osteolysis intervention and bone regeneration.Materials today. Bio · 2025Article
- Article
- Calcium Phosphates: A Key to Next-Generation In Vitro Bone Modeling.Advanced healthcare materials · 2024Review
- Personalized bioceramic grafts for craniomaxillofacial bone regeneration.International journal of oral science · 2024Review
- Functional Scaffolds for Bone Tissue Regeneration: A Comprehensive Review of Materials, Methods, and Future Directions.Journal of functional biomaterials · 2024Review
- Review
- Biomimetic Scaffolds of Calcium-Based Materials for Bone Regeneration.Biomimetics (Basel, Switzerland) · 2024Review
- Research trends of bone tumor treatment with 3D printing technology from 2013 to 2022: a bibliometric analysis.Discover oncology · 2024Article
- Smurf1-targeting microRNA-136-5p-modified bone marrow mesenchymal stem cells combined with 3D-printed β-tricalcium phosphate scaffolds strengthen osteogenic activity and alleviate bone defects.The Kaohsiung journal of medical sciences · 2024Article
33 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A challenge in regenerating large bone defects under load is to create scaffolds with large and interconnected pores while providing a compressive strength comparable to cortical bone (100-150 MPa). Here we design a novel hexagonal architecture for a glass-ceramic scaffold to fabricate an anisotropic, highly porous three dimensional scaffolds with a compressive strength of 110 MPa. Scaffolds with hexagonal design demonstrated a high fatigue resistance (1,000,000 cycles at 1-10 MPa compressive cyclic load), failure reliability and flexural strength (30 MPa) compared with those for conventional architecture. The obtained strength is 150 times greater than values reported for polymeric and composite scaffolds and 5 times greater than reported values for ceramic and glass scaffolds at similar porosity. These scaffolds open avenues for treatment of load bearing bone defects in orthopaedic, dental and maxillofacial applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.