ArticleNeuroscience bulletin2016
Characterization of Rebound Depolarization in Neurons of the Rat Medial Geniculate Body In Vitro.
Article in Neuroscience bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- A comprehensive review of HCN channel expression and IJournal of neurophysiology · 2025Review
- Light-Driven Sodium Pump as a Potential Tool for the Control of Seizures in Epilepsy.Molecular neurobiology · 2024Article
- Disinhibition Is an Essential Network Motif Coordinated by GABA Levels and GABA B Receptors.International journal of molecular sciences · 2024Review
- Predictability alters multisensory responses by modulating unisensory inputs.Frontiers in neuroscience · 2023Article
- Optogenetic activation of the inhibitory nigro-collicular circuit evokes contralateral orienting movements in mice.Cell reports · 2022Article
- From Receptive to Perceptive Fields: Size-Dependent Asymmetries in Both Negative Afterimages and Subcortical On and Off Post-Stimulus Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Electrophysiological and Morphological Features of Rebound Depolarization Characterized Interneurons in Rat Superficial Spinal Dorsal Horn.Frontiers in cellular neuroscience · 2021Article
- Post-stimulatory activity in primate auditory cortex evoked by sensory stimulation during passive listening.Scientific reports · 2020Article
- Asymmetries of Dark and Bright Negative Afterimages Are Paralleled by Subcortical ON and OFF Poststimulus Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- [Rebound depolarization of substantia gelatinosa neurons and its modulatory mechanisms in rat spinal dorsal horn].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2016Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rebound depolarization (RD) is a response to the offset from hyperpolarization of the neuronal membrane potential and is an important mechanism for the synaptic processing of inhibitory signals. In the present study, we characterized RD in neurons of the rat medial geniculate body (MGB), a nucleus of the auditory thalamus, using whole-cell patch-clamp and brain slices. RD was proportional in strength to the duration and magnitude of the hyperpolarization; was effectively blocked by Ni(2+) or Mibefradil; and was depressed when the resting membrane potential was hyperpolarized by blocking hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with ZD7288 or by activating G-protein-gated inwardly-rectifying K(+) (GIRK) channels with baclofen. Our results demonstrated that RD in MGB neurons, which is carried by T-type Ca(2+) channels, is critically regulated by HCN channels and likely by GIRK channels.
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