Evidence map›Paper›PMID 26781836›Full record

ArticleThe Journal of pediatrics2016

School-Aged Outcomes following Prenatal Methamphetamine Exposure: 7.5-Year Follow-Up from the Infant Development, Environment, and Lifestyle Study.

Nwando Eze, Lynne M Smith, Linda L LaGasse, Chris Derauf, Elana Newman, Amelia Arria, Marilyn A Huestis, Sheri A Della Grotta, Lynne M Dansereau, Charles Neal and 1 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Methamphetamine: burden, mechanism and impact on pregnancy, the fetus, and newborn.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Review
  8. Article
  9. Review
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Nwando EzeDepartment of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles (UCLA) and Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.
Lynne M SmithDepartment of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles (UCLA) and Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA. Electronic address: smith@labiomed.org.
Linda L LaGassePediatrics Division, Brown Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, RI.
Chris DeraufJohn A. Burns School of Medicine, University of Hawaii, Honolulu, HI.
Elana NewmanDepartment of Psychology, The University of Tulsa, Tulsa, OK.
Amelia ArriaCenter for Substance Abuse Research, University of Maryland, College Park, MD.
Marilyn A HuestisSection on Chemistry and Drug Metabolism, National Institute on Drug Abuse, Bethesda, MD.
Sheri A Della GrottaPediatrics Division, Brown Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, RI.
Lynne M DansereauPediatrics Division, Brown Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, RI.
Charles NealJohn A. Burns School of Medicine, University of Hawaii, Honolulu, HI.
Barry M LesterPediatrics Division, Brown Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, RI.
Brown University · USUniversity of California, Los Angeles · USUniversity of Hawaiʻi at Mānoa · USNational Institute on Drug Abuse · USUniversity of Maryland, College Park · USUniversity of Tulsa · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Prental Methamphetamine Exposure and Child DevelopmentR01DA014948 · NIDA · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LESTER, BARRY M. · 2001 to 2013
$14.5M
RESEARCH ETHICSU54RR026136 · NCRR · UNIVERSITY OF HAWAII AT MANOA · PI HEDGES, JERRIS R · 2010 to 2011
$8.5M
NCATS NIH HHS CTSI UL1TR000124NCATS NIH HHS UL1 TR000124NCRR NIH HHS U54 RR026136NCRR NIH HHS U54RR026136NIDA NIH HHS R01DA014918NIDA NIH HHS R01 DA014948
6 · The paper itself

Abstract

objectiveTo assess the relationship between prenatal methamphetamine exposure (PME) and behavior problems at age 7.5 years and the extent to which early adversity mediated this relationship. STUDY

designThe multicenter, longitudinal Infant Development, Environment, and Lifestyle study enrolled 412 mother-infant pairs at 4 sites. Methamphetamine-exposed participants (n = 204) were identified by self-report and/or gas chromatography/mass spectrometry confirmation of amphetamine and metabolites in infant meconium. Matched participants (n = 208) denied methamphetamine use and had a negative meconium screen. At the 7.5-year follow-up, 290 children with complete Child Behavior Checklist data and an early adversity index score were available for analysis (n = 146 exposed).

resultsPME was significantly associated with an increased early adversity index score (P < .001) and with increased externalizing, rule-breaking behavior, and aggressive behavior (P < .05). Early adversity was also associated with higher externalizing behavior scores. Early adversity significantly mediated the relationship between PME and behavioral problems. After adjusting the mediation model for sex, prenatal tobacco, alcohol, and marijuana exposures, and study site, the association of PME with early adversity remained significant.

conclusionsThough PME is associated with behavioral problems, early adversity may be a strong determinant of behavioral outcome for children exposed to methamphetamine in utero. Early adversity significantly mediated the relationship between PME and behavioral problems.

Indexed as

Amphetamine-Related DisordersCentral Nervous System StimulantsChildChild BehaviorChild, PreschoolDevelopmental DisabilitiesEnvironmentFemaleFollow-Up StudiesGas Chromatography-Mass SpectrometryHumansInfantInfant, NewbornLife StyleLongitudinal StudiesMaleCentral Nervous System StimulantsMethamphetamine

Identifiers

PMID26781836
PMCPMC4769906
OpenAlexW2229040133

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.