ArticleClinical rheumatology2016
Prevalence of positive autoimmune biomarkers in the brucellosis patients.
Article in Clinical rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Frequency of Human Brucellosis Complications in West Asia: A Systematic Review and Meta-Analysis.MicrobiologyOpen · 2026Pooled it
- Research progress on serological indices and their clinical application in rheumatoid arthritis.Journal of clinical laboratory analysis · 2022Pooled it
- Laboratory-AcquiredPathogens (Basel, Switzerland) · 2026Article
- Deep Vein Thrombosis Secondary to Brucellosis: An Uncommon Infectious Cause of Venous Thrombosis.Case reports in infectious diseases · 2026Article
- Brucellosis complicated by aortitis and thyroiditis: a case report.BMC infectious diseases · 2025Article
- Clinical efficacy of arthroscopy combined with irrigation and drainage in the treatment of brucellosis of the hip.International orthopaedics · 2023Article
- A Challenging Diagnosis of Febrile Pancytopenia in a Patient With a History of Autoimmune Disease.Cureus · 2023Article
- Prevalence and relevant factors of positive RF in brucellosis patients with arthralgia.PLoS neglected tropical diseases · 2021Article
- Osteoarticular manifestations of human brucellosis: A review.World journal of orthopedics · 2019Review
- Brucella Peptide Cross-Reactive Major Histocompatibility Complex Class I Presentation Activates SIINFEKL-Specific T Cell Receptor-Expressing T Cells.Infection and immunity · 2018Article
- An Interesting Case of Neurobrucellosis Mimicking Neuropsychiatric Lupus.Case reports in rheumatology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brucellosis is a chronic infectious disease with articular involvement. Discrimination between brucellosis and rheumatologic disorders is difficult in regions endemic for brucellosis. There are few studies about the rate of positive autoantibodies as rheumatologic biomarkers in brucellosis, and the prevalence is variable. In this study, the rheumatologic tests were studied in brucellosis patients. This cross sectional study was performed in two teaching hospitals in Tehran, Iran. Forty-nine patients with brucella infection and 42 healthy participants were enrolled in this study. Brucellosis was diagnosed on the basis of the clinical symptoms and positive serology for brucellosis. Rheumatic factor (RF) and antinuclear antibodies (ANA) were evaluated in all patients. Cyclic citrullinated peptides antibody (ACPA) and anti-double strand DNA (anti-dsDNA) were checked in all patients and control groups. Out of 49 patients, 15 (30.6 %) were RF positive and 4 (8.2 %) were ANA positive. Anti-dsDNA was concurrently positive with ANA in 1 patient (2 %) but ACPA titer was positive in 8 patients (16.3 %). None of the patients with positive autoantibody biomarkers fulfilled the criteria for rheumatologic disorders. The rate of positive RF in healthy people was significantly lower than patient group (2.4 vs. 30.6 %), but the positiveness rate of other biomarkers did not have significant difference in two groups. Sixty percent of the patients with positive RF and 75 % with positive ACPA had skeletal involvement (P < 0.05). Autoantibody biomarkers can be positive in brucellosis. Rheumatologists should be aware of brucellosis in patients with musculoskeletal involvement and positive autoantibody biomarkers in endemic regions.
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Registered trials
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