ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2016
Increased body fat is associated with potentiation of blood pressure response to hypoxia in healthy men: relations with insulin and leptin.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives.Frontiers in neuroscience · 2024Review
- Exploring the Mediators that Promote Carotid Body Dysfunction in Type 2 Diabetes and Obesity Related Syndromes.International journal of molecular sciences · 2020Review
- The Role of Leptin Levels in Adaptation to Cold Climates.International journal of environmental research and public health · 2020Article
- Anthropometric Measures as Predictive Indicators of Metabolic Risk in a Population of "Holy WeekInternational journal of environmental research and public health · 2019Article
- Improved glucose homeostasis in male obese Zucker rats coincides with enhanced baroreflexes and activation of the nucleus tractus solitarius.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Baroreflex gain and vasomotor sympathetic modulation in resistant hypertension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2017Article
- Leptin decreases the expression of low-density lipoprotein receptor via PCSK9 pathway: linking dyslipidemia with obesity.Journal of translational medicine · 2016Article
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6 authors.
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Abstract
backgroundIncreased peripheral chemosensitivity (PChS) has been proposed as mechanism underlying obesity-related sympathoactivation, with insulin and/or leptin as possible mediators. However, human data on PChS in obesity are scarce. Therefore, we explored this issue in a sample of 41 healthy men aged 30-59 years, divided according to body fat percentage (fat %) into two groups: <25 and ≥25 %.
methodsPChS was assessed using transient hypoxia method [respiratory (PChS-MV), heart rate (PChS-HR), and blood pressure (PChS-SBP) responses were calculated]. Baroreflex sensitivity (BRS-Seq) was assessed using sequence method. Fasting plasma insulin and leptin levels were measured. Homeostatic model assessment (HOMA) was used to assess insulin sensitivity/resistance.
resultsIndividuals with ≥25 % body fat demonstrated increased PChS-SBP (p < 0.01), but unchanged PChS-MV and PChS-HR (both p > 0.4). PChS-SBP was related positively with anthropometric characteristics (e.g. waist circumference, fat %), plasma insulin and HOMA (all p < 0.05), and negatively with BRS-Seq (p = 0.001), but not with plasma leptin (p = 0.27).
conclusionsIn healthy men, overweight/obesity is accompanied by augmented blood pressure response from peripheral chemoreceptors, while respiratory and heart rate responses remain unaltered. Hyperinsulinaemia and insulin resistance (but not hyperleptinaemia) are associated with augmented pressure response from chemoreceptors.
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