ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2016
[Association between anxiety-depression and 5-HTTLPR gene polymorphism in school-aged twins].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 2 citations in OpenAlex.
- [Current status of social anxiety among primary school students with myopia in Urumqi, China and risk factors for myopia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
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5 authors at 1 institution in 1 country.
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Abstract
objectiveTo investigate the association between anxiety-depression and 5-HTTLPR gene polymorphism in school-aged twins.
methodsA total of 147 pairs of twins (47 pairs of monozygotic twins, 100 pairs of dizygotic twins) aged 8-12 years from Baotou and Hohhot were selected as respondents. The Achenbach Child Behavior Checklist (CBCL) was used to calculate the scores of anxiety-depression factors in school-aged twins. The DNA was extracted from oral epithelial cells, and polymerase chain reaction was applied for 5-HTTLPR genotyping. The generalized estimating equation (GEE) was used to analyze the effect of 5-HTTLPR polymorphism and family environment on anxiety-depression in school-aged twins.
resultsThe children with LS and SS genotypes had significantly higher scores of anxiety-depression factors than those with LL genotype (χ2=3.938, P<0.05). The interaction of 5-HTTLPR genotype with family cohesion and family rearing patterns had a significant impact on the scores of anxiety-depression factors in twins (χ2=6.129 and 7.665, both P<0.05).
conclusions5-HTTLPR genotype is significantly correlated with the scores of anxiety-depression factors in school-aged twins. In the family with high cohesion and an autocratic family rearing pattern, S allele may increase the possibility of anxiety-depression in twin children.
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26781415PMC7390101W2464107090What OpenQuestion holds
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