Evidence map›Paper›PMID 26781315›Full record

ArticleProbiotics and antimicrobial proteins2010

Differential Effect of Lactobacillus johnsonii BFE 6128 on Expression of Genes Related to TLR Pathways and Innate Immunity in Intestinal Epithelial Cells.

Stephanie Seifert, Manuel Rodriguez Gómez, Bernhard Watzl, Wilhelm H Holzapfel, Charles M A P Franz, María G Vizoso Pinto

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Stephanie SeifertDepartment of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, Federal Research Institute for Nutrition and Food, Haid-und-Neu-Strasse 9, 76131, Karlsruhe, Germany.
Manuel Rodriguez GómezDepartment of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut, Federal Research Institute for Nutrition and Food, Haid-und-Neu-Strasse 9, 76131, Karlsruhe, Germany.
Bernhard WatzlDepartment of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, Federal Research Institute for Nutrition and Food, Haid-und-Neu-Strasse 9, 76131, Karlsruhe, Germany.
Wilhelm H HolzapfelDepartment of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut, Federal Research Institute for Nutrition and Food, Haid-und-Neu-Strasse 9, 76131, Karlsruhe, Germany.
Charles M A P FranzDepartment of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut, Federal Research Institute for Nutrition and Food, Haid-und-Neu-Strasse 9, 76131, Karlsruhe, Germany.
María G Vizoso PintoDepartment of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut, Federal Research Institute for Nutrition and Food, Haid-und-Neu-Strasse 9, 76131, Karlsruhe, Germany. vizoso@mvp.uni-muenchen.de.
Max Rubner Institut · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotics have been shown to enhance immune defenses, but their mechanisms of action are only partially understood. We investigated the modulation of signal pathways involved in innate immunity in enterocytes by Lactobacillus johnsonii BFE 6128 isolated from 'Kule naoto', a Maasai traditional fermented milk product. This lactobacillus sensitized HT29 intestinal epithelial cells toward recognition of Salmonella enterica serovar Typhimurium by increasing the IL-8 levels released after challenge with this pathogen and by differentially modulating genes related to toll-like receptor (TLR) pathways and innate immunity. Thus, the modulation of pro-inflammatory mediators and TLR-pathway-related molecules may be an important mechanism contributing to the potential stimulation of innate immunity by lactobacilli at the intestinal epithelial level.

Indexed as

AdjuvantIL-8Innate immunityIntestinal epithelial cellLactobacillusProbiotics

Identifiers

PMID26781315
OpenAlexW1979068308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.