ArticleMicrobiology (Reading, England)2016
MsaB activates capsule production at the transcription level in Staphylococcus aureus.
Article in Microbiology (Reading, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- Regulation of Staphylococcal Capsule by SarZ is SigA-Dependent.Journal of bacteriology · 2022Article
- Delineating the Role of theFrontiers in microbiology · 2022Article
- Antibiotic Resistance Crisis: An Update on Antagonistic Interactions between Probiotics and Methicillin-Resistant Staphylococcus aureus (MRSA).Current microbiology · 2021Review
- Review
- Characterization of Antibiotic Resistance and Virulence Traits Present in Clinical Methicillin-Resistant Staphylococcus aureus Isolates.Current microbiology · 2021Article
- TheFrontiers in microbiology · 2021Article
- MgrA Activates Staphylococcal Capsule via SigA-Dependent Promoter.Journal of bacteriology · 2020Article
- The role of the msaABCR operon in implant-associated chronic osteomyelitis in Staphylococcus aureus USA300 LAC.BMC microbiology · 2020Article
- The Impacts ofInfection and immunity · 2020Article
- TheJournal of bacteriology · 2019Article
- Role of theAntimicrobial agents and chemotherapy · 2019Article
- CspA regulation of Staphylococcus aureus carotenoid levels and σMolecular microbiology · 2019Article
- Repression of Capsule Production by XdrA and CodY in Staphylococcus aureus.Journal of bacteriology · 2018Article
- MsaB and CodY Interact To Regulate Staphylococcus aureus Capsule in a Nutrient-Dependent Manner.Journal of bacteriology · 2018Article
- Guanine Limitation Results in CodY-Dependent and -Independent Alteration of Staphylococcus aureus Physiology and Gene Expression.Journal of bacteriology · 2018Article
- msaABCR operon is involved in persister cell formation in Staphylococcus aureus.BMC microbiology · 2017Article
- Growth-dependent activity of the cold shock cspA promoter + 5' UTR and production of the protein CspA in Staphylococcus aureus Newman.BMC research notes · 2017Article
- Cold-Shock Domain Family Proteins (Csps) Are Involved in Regulation of Virulence, Cellular Aggregation, and Flagella-Based Motility inFrontiers in cellular and infection microbiology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Staphylococcus aureus produces several virulence factors that allow it to cause a variety of infections. One of the major virulence factors is the capsule, which contributes to the survival of the pathogen within the host as a way to escape phagocytosis. The production of the capsular polysaccharide is encoded in a 16 gene operon, which is regulated in response to several environmental stimuli including nutrient availability. For instance, the capsule is produced in the late- and post-exponential growth phases, but not in the early- or mid-exponential growth phase. Several regulators are involved in capsule production, but the regulation of the cap operon is still poorly understood. In this study, we show that MsaB activates the cap operon by binding directly to a 10 bp repeat in the promoter region. We show that despite the fact that MsaB is expressed throughout four growth phases, it only activates capsule production in the late- and post-exponential growth phases. Furthermore, we find that MsaB does not bind to its target site in the early and mid-exponential growth phases. This correlates with decreased nutrient availability and capsule production. These data suggest either that MsaB binding ability changes in response to nutrients or that other cap operon regulators interfere with the binding of MsaB to its target site. This study increases our understanding of the regulation of capsule production and the mechanism of action of MsaB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.