Evidence map›Paper›PMID 26781276›Full record

ArticleHypertension (Dallas, Tex. : 1979)2016

Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II-Dependent Hypertension in Mice.

Paramita Pati, David J R Fulton, Zsolt Bagi, Feng Chen, Yusi Wang, Julia Kitchens, Lisa A Cassis, David W Stepp, R Daniel Rudic

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Hypertension disrupts the vascular clock in both sexes.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  4. Artificial light at night affects the daily profile of pulse pressure and protein expression in the thoracic aorta of rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Article
  5. Review
  6. Review
  7. Article
  8. Impacts of Circadian GeneOxidative medicine and cellular longevity · 2022
    Article
  9. A wrinkle in time: circadian biology in pulmonary vascular health and disease.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
  10. Circadian Control of Sodium and Blood Pressure Regulation.American journal of hypertension · 2021
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Old and New Roles and Evolving Complexities of Cardiovascular Clocks.The Yale journal of biology and medicine · 2019
    Review
  19. Circadian regulation of renal function.Free radical biology & medicine · 2018
    Review
  20. Circadian clock-mediated regulation of blood pressure.Free radical biology & medicine · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Paramita PatiFrom the Departments of Pharmacology and Toxicology (P.P., D.J.R.F., J.K., R.D.R.), Medicine (Z.B.), and Physiology (D.W.S.), Vascular Biology Center (D.J.R.F., Z.B., F.C., Y.W., D.W.S.), Medical College of Georgia at Augusta University; and Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington (L.A.C.).
David J R FultonFrom the Departments of Pharmacology and Toxicology (P.P., D.J.R.F., J.K., R.D.R.), Medicine (Z.B.), and Physiology (D.W.S.), Vascular Biology Center (D.J.R.F., Z.B., F.C., Y.W., D.W.S.), Medical College of Georgia at Augusta University; and Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington (L.A.C.).
Zsolt BagiFrom the Departments of Pharmacology and Toxicology (P.P., D.J.R.F., J.K., R.D.R.), Medicine (Z.B.), and Physiology (D.W.S.), Vascular Biology Center (D.J.R.F., Z.B., F.C., Y.W., D.W.S.), Medical College of Georgia at Augusta University; and Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington (L.A.C.).
Feng ChenFrom the Departments of Pharmacology and Toxicology (P.P., D.J.R.F., J.K., R.D.R.), Medicine (Z.B.), and Physiology (D.W.S.), Vascular Biology Center (D.J.R.F., Z.B., F.C., Y.W., D.W.S.), Medical College of Georgia at Augusta University; and Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington (L.A.C.).
Yusi WangFrom the Departments of Pharmacology and Toxicology (P.P., D.J.R.F., J.K., R.D.R.), Medicine (Z.B.), and Physiology (D.W.S.), Vascular Biology Center (D.J.R.F., Z.B., F.C., Y.W., D.W.S.), Medical College of Georgia at Augusta University; and Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington (L.A.C.).
Julia KitchensFrom the Departments of Pharmacology and Toxicology (P.P., D.J.R.F., J.K., R.D.R.), Medicine (Z.B.), and Physiology (D.W.S.), Vascular Biology Center (D.J.R.F., Z.B., F.C., Y.W., D.W.S.), Medical College of Georgia at Augusta University; and Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington (L.A.C.).
Lisa A CassisFrom the Departments of Pharmacology and Toxicology (P.P., D.J.R.F., J.K., R.D.R.), Medicine (Z.B.), and Physiology (D.W.S.), Vascular Biology Center (D.J.R.F., Z.B., F.C., Y.W., D.W.S.), Medical College of Georgia at Augusta University; and Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington (L.A.C.).
David W SteppFrom the Departments of Pharmacology and Toxicology (P.P., D.J.R.F., J.K., R.D.R.), Medicine (Z.B.), and Physiology (D.W.S.), Vascular Biology Center (D.J.R.F., Z.B., F.C., Y.W., D.W.S.), Medical College of Georgia at Augusta University; and Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington (L.A.C.).
R Daniel RudicFrom the Departments of Pharmacology and Toxicology (P.P., D.J.R.F., J.K., R.D.R.), Medicine (Z.B.), and Physiology (D.W.S.), Vascular Biology Center (D.J.R.F., Z.B., F.C., Y.W., D.W.S.), Medical College of Georgia at Augusta University; and Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington (L.A.C.). rrudic@gru.edu.
University of Kentucky · US

Funding

Therapeutic Mechanisms of RhoA Inhibition In Acute Lung InjuryP01HL101902 · NHLBI · AUGUSTA UNIVERSITY · PI BLACK, STEPHEN M · 2011 to 2016
$11.2M
Novel mechanistic pathways of cardiovascular disease in obesityR01HL124773 · NHLBI · AUGUSTA UNIVERSITY · PI FULTON, DAVID J, STEPP, DAVID W · 2015 to 2018
$2.2M
The biological clock, the endothelium, and vascular remodelingR01HL089576 · NHLBI · AUGUSTA UNIVERSITY · PI RUDIC, RADU DANIEL · 2008 to 2012
$2.1M
NHLBI NIH HHS P01 HL101902NHLBI NIH HHS R01 HL089576NHLBI NIH HHS R01HL089576NHLBI NIH HHS R01 HL124773
6 · The paper itself

Abstract

Blood pressure exhibits a robust circadian rhythm in health. In hypertension, sleep apnea, and even shift work, this balanced rhythm is perturbed via elevations in night-time blood pressure, inflicting silent damage to the vasculature and body organs. Herein, we examined the influence of circadian dysfunction during experimental hypertension in mice. Using radiotelemetry to measure ambulatory blood pressure and activity, the effects of angiotensin II administration were studied in wild-type (WT) and period isoform knockout (KO) mice (Per2-KO, Per2, 3-KO, and Per1, 2, 3-KO/Per triple KO [TKO] mice). On a normal diet, administration of angiotensin II caused nondipping blood pressure and exacerbated vascular hypertrophy in the Period isoform KO mice relative to WT mice. To study the endogenous effects of angiotensin II stimulation, we then administered a low-salt diet to the mice, which does stimulate endogenous angiotensin II in addition to lowering blood pressure. A low-salt diet decreased blood pressure in wild-type mice. In contrast, Period isoform KO mice lost their circadian rhythm in blood pressure on a low-salt diet, because of an increase in resting blood pressure, which was restorable to rhythmicity by the angiotensin receptor blocker losartan. Chronic administration of low salt caused vascular hypertrophy in Period isoform KO mice, which also exhibited increased renin levels and altered angiotensin 1 receptor expression. These data suggest that circadian clock genes may act to inhibit or control renin/angiotensin signaling. Moreover, circadian disorders such as sleep apnea and shift work may alter the homeostatic responses to sodium restriction to potentially influence nocturnal hypertension.

Indexed as

Diet, Sodium-RestrictedAngiotensin IIAnimalsBlood PressureCircadian RhythmDisease Models, AnimalHypertensionMaleMiceMice, KnockoutSodium Chloride, DietaryAngiotensin IISodium Chloride, Dietaryagingangiotensincircadianhypertensionhypertrophyreninsodium

Identifiers

PMID26781276
PMCPMC4752410
OpenAlexW2271027602

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.