Evidence map›Paper›PMID 26781241›Full record

ArticleProbiotics and antimicrobial proteins2010

Probiotic Lactobacillus and Bifidobacterial Lectins Against Candida albicans and Staphylococcus aureus Clinical Strains: New Class of the Pathogen Biofilm Destructors.

M Lakhtin, V Alyoshkin, V Lakhtin, S Afanasyev, L Pozhalostina, V Pospelova

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 53 citations in OpenAlex.

  1. Vitamin BCommunications biology · 2025
    Article
  2. Article
  3. Microorganisms · 2025
    Review
  4. Genome-Guided Identification of Surfactin-ProducingInternational journal of molecular sciences · 2024
    Article
  5. Mining the nanotube-formingComputational and structural biotechnology journal · 2023
    Article
  6. Article
  7. Review
  8. Review
  9. Anticandidal Activities byFrontiers in oral health · 2021
    Review
  10. Application of Probiotic Yeasts onJournal of fungi (Basel, Switzerland) · 2020
    Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

M LakhtinG.N. Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia.
V AlyoshkinG.N. Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia.
V LakhtinG.N. Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia. lakhtinv@yandex.ru.
S AfanasyevG.N. Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia.
L PozhalostinaG.N. Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia.
V PospelovaG.N. Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia.
Gabrichevsky Institute of Epidemiology and Microbiology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preparations of probiotic bifidobacterial and lactobacillus lectins possessed system affinity to mannan and mucin-type polymers. It was shown that these lectins possess fungistatic and fungicidal activities against nystatin-resistant Candida albicans clinical strains. Lectins revealed destructive properties with respect to C. albicans and Staphylococcus aureus biofilms, depending on clinical strain origin and lectin preparation type. Synergistic antipathogen activities between lectins and between lectins and nystatin were observed. In the presence of lectins, pathogen biofilm degradation occurred in sequential steps, including biofilm refinement, appearance of edge cavities, segmentation, detachment of fragments and their lysis. Fungal response to lectins was more complex compared to that of staphylococci. Cold stress improved pictures of lectin antipathogen action. The data indicate that probiotic bacterial lectins are members of a new class of antimicrobials-destructors of pathogen biofilms.

Indexed as

AntimicrobialsBiofilmsCandida albicansClinical strainsLectinsProbioticsStaphylococcus aureusSynergistic action

Identifiers

PMID26781241
OpenAlexW1982376119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.