ArticleProbiotics and antimicrobial proteins2010
Probiotic-Induced Priming of Innate Immunity to Protect Against Rotaviral Infection.
Article in Probiotics and antimicrobial proteins, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Randomized, Double-blind, Placebo-controlled Study of a Multispecies Probiotic Mixture in Nonalcoholic Fatty Liver Disease.Scientific reports · 2019Trial
- Interplay between nutrition, microbiota, and immunity in rotavirus infection: insights from human and animal models.Frontiers in veterinary science · 2025Review
- Effect of probiotic bacteria on porcine rotavirus OSU infection of porcine intestinal epithelial IPEC-J2 cells.Archives of virology · 2022Article
- Microbiota Depletion Promotes Human Rotavirus Replication in an Adult Mouse Model.Biomedicines · 2021Article
- Interaction of Intestinal Bacteria with Human Rotavirus during Infection in Children.International journal of molecular sciences · 2021Article
- Article
- Probiotic legacy effects on gut microbial assembly in tilapia larvae.Scientific reports · 2016Article
- Comparative Analysis of the Effects of Two Probiotic Bacterial Strains on Metabolism and Innate Immunity in the RAW 264.7 Murine Macrophage Cell Line.Probiotics and antimicrobial proteins · 2016Article
- Noroviral p-particles as an in vitro model to assess the interactions of noroviruses with probiotics.PloS one · 2014Article
- In Vitro Investigation of the Immunomodulatory Potential of Probiotic Lactobacillus casei.Probiotics and antimicrobial proteins · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding of probiotic-induced regulatory gene expression and networking is critical to further explore their roles in controlling infection. Transcriptional profile of selected innate immune genes in primary bovine intestinal epithelial cells was assessed over a time course of incubation with the probiotic Lactobacillus plantarum 299v. Based on gene expression results, a time point was chosen to prime epithelial cells with the probiotic prior to infection with rotavirus. Plaque assays and genomic analysis provided the basis for establishing the efficacy of probiotics in preventing a rotaviral infection. Plaque assays revealed that the probiotic is capable of decreasing (at least by 100-fold) the levels of live virus when the cells were primed with the probiotic. Results from gene expression studies (a) suggested that homeostasis in the gut is maintained in probiotic-primed cells despite infection with rotavirus and (b) revealed preliminary mechanisms for understanding the pathway of pathogen protection by using probiotics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.