ArticleProceedings of the National Academy of Sciences of the United States of America1989
Differential binding of nuclear factors to the intron 1 sequences containing the transcriptional pause site correlates with c-myb expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- Analysis of a Genetic Polymorphism in the Costimulatory Molecule TNFSF4 with Hematopoietic Stem Cell Transplant Outcomes.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2016Article
- MYB elongation is regulated by the nucleic acid binding of NFκB p50 to the intronic stem-loop region.PloS one · 2015Article
- Three murine leukemia virus integration regions within 100 kilobases upstream of c-myb are proximal to the 5' regulatory region of the gene through DNA looping.Journal of virology · 2012Article
- Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development.The EMBO journal · 2012Article
- Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage.Molecular and cellular biology · 2001Article
- HTLV-I Tax transrepresses the human c-Myb promoter independently of its interaction with CBP or p300.Oncogene · 2000Article
- Article
- Elements within the beta-lactoglobulin gene inhibit expression of human serum albumin cDNA and minigenes in transfected cells but rescue their expression in the mammary gland of transgenic mice.Nucleic acids research · 1996Article
- Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation.Molecular and cellular biology · 1993Article
- Stability of Drosophila RNA polymerase II elongation complexes in vitro.Molecular and cellular biology · 1992Article
- Control of formation of two distinct classes of RNA polymerase II elongation complexes.Molecular and cellular biology · 1992Article
- Transactivation of erythroid transcription factor GATA-1 by a myb-ets-containing retrovirus.Journal of virology · 1992Article
- Altered chromosome 6 in immortal human fibroblasts.Molecular and cellular biology · 1992Article
- Positive autoregulation of c-myb expression via Myb binding sites in the 5' flanking region of the human c-myb gene.Molecular and cellular biology · 1991Article
- Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins.Molecular and cellular biology · 1991Article
- Sequence requirements for premature transcription arrest within the first intron of the mouse c-fos gene.Molecular and cellular biology · 1991Article
- Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
The molecular mechanisms that modulate c-myb mRNA levels in hematopoietic cells appear to involve premature termination of transcription in the first intron of the gene. We have examined the DNA-protein interactions within the first intron of the c-myb gene and identified a 1.0-kilobase region that could be responsible for its transcriptional regulation. Using the mobility-shift assay, we show a direct correlation between the extent of sequence-specific protein binding to intron 1 DNA fragments, and c-myb mRNA levels in different cell types. During dimethyl sulfoxide-induced differentiation of mouse erythroleukemic cells, there was a dramatic decrease in these nuclear factors that correlated with the decrease in the levels of c-myb mRNA. Nucleotide sequence analysis and DNase I footprinting revealed the presence of putative regulatory elements that are implicated in the binding of these nuclear factors. We propose that binding of nuclear factors to the site of transcriptional pause could play an important role in the regulation of c-myb transcription.
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