Evidence map›Paper›PMID 26780893›Full record

ArticleArchives of virology2016

The fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin.

Tung Gia Phan, Antonio Charlys da Costa, Juana Del Valle Mendoza, Filemon Bucardo-Rivera, Johan Nordgren, Miguel O'Ryan, Xutao Deng, Eric Delwart

Open access · greenAbstract read
In one paragraph

Article in Archives of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Gut virome in early life: origins and implications.Current opinion in virology · 2022
    Review
  6. Article
  7. Article
  8. Viruses associated with ill health in wild chimpanzees.American journal of primatology · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Emerging Roles of Gut Virome in Pediatric Diseases.International journal of molecular sciences · 2021
    Review
  14. Article
  15. Redondovirus DNA in human respiratory samples.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 6 countries.

Tung Gia PhanBlood Systems Research Institute, San Francisco, CA, 94118, USA.
Antonio Charlys da CostaBlood Systems Research Institute, San Francisco, CA, 94118, USA.
Juana Del Valle MendozaFaculty of Health Sciences, School of Medicine, Universidad Peruana de Ciencias Aplicadas-UPC, Lima, Peru.
Filemon Bucardo-RiveraDepartment of Microbiology, University of León, León, Nicaragua.
Johan NordgrenDivision of Molecular Virology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Miguel O'RyanMicrobiology and Mycology Program, Faculty of Medicine, University of Chile, Santiago, Chile.
Xutao DengBlood Systems Research Institute, San Francisco, CA, 94118, USA.
Eric DelwartBlood Systems Research Institute, San Francisco, CA, 94118, USA. delwarte@medicine.ucsf.edu.
University of California, San Francisco · USBlood Systems Research Institute · USLinköping University · SEPeruvian University of Applied Sciences · PEUniversidade de São Paulo · BRUniversidad Nacional Autónoma de Nicaragua-León · NIUniversity of Chile · CL

Funding

Metagenomic detection of emerging viruses in the blood supplyR01HL105770 · NHLBI · VITALANT · PI DELWART, ERIC L · 2011 to 2015
$2.4M
NHLBI NIH HHS R01 HL105770
6 · The paper itself

Abstract

Viral metagenomics of feces collected from 58 Peruvian children with unexplained diarrhea revealed several small circular ssDNA genomes. Two genomes related to sequences previously reported in feces from chimpanzees and other mammals and recently named smacoviruses were characterized and then detected by PCR in 1.7 % (1/58) and 19 % (11/58) of diarrheal samples, respectively. Another three genomes from a distinct small circular ssDNA viral group provisionally called pecoviruses encoded Cap and Rep proteins with <35 % identity to those in related genomes reported in human, seal, porcine and dromedary feces. Pecovirus DNA was detected in 15.5 % (9/58), 5.9 % (3/51) and 3 % (3/100) of fecal samples from unexplained diarrhea in Peru, Nicaragua and Chile, respectively. Feces containing these ssDNA genomes also contained known human enteric viral pathogens. The cellular origins of these circular ssDNA viruses, whether human cells, ingested plants, animals or fungal foods, or residents of the gut microbiome, are currently unknown.

Indexed as

ChileDiarrheaDNA, CircularDNA, ViralFecesGenome, ViralHumansNicaraguaPeruPhylogenyVirus DiseasesDNA, CircularDNA, Viral

Identifiers

PMID26780893
PMCPMC4814309
OpenAlexW2273182635

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.