Evidence map›Paper›PMID 26780873›Full record

ReviewAsian journal of andrology

Specialized sperm function tests in varicocele and the future of andrology laboratory.

Ahmad Majzoub, Sandro C Esteves, Jaime Gosálvez, Ashok Agarwal

Abstract readReview
In one paragraph

Review in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021
    Review
  7. Article
  8. Review
  9. Article
  10. Treating varicocele in 2018: current knowledge and treatment options.Journal of endocrinological investigation · 2018
    Review
  11. Review
  12. Effect of varicocele repair on sperm DNA fragmentation: a review.International urology and nephrology · 2018
    Review
  13. Article
  14. Article
  15. Article
  16. Understanding sperm DNA fragmentation.Translational andrology and urology · 2017
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ahmad MajzoubGlickman Urological and Kidney Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Sandro C Esteves
Jaime Gosálvez
Ashok Agarwal

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Varicocele is a common medical condition entangled with many controversies. Though it is highly prevalent in men with infertility, still it marks its presence in males who do have normal fertility. Determining which patients are negatively affected by varicocele would enable clinicians to better select those men who benefitted the most from surgery. Since conventional semen analysis has been limited in its ability to evaluate the negative effects of varicocele on fertility, a multitude of specialized laboratory tests have emerged. In this review, we examine the role and significance of specialized sperm function tests with regards to varicocele. Among the various tests, analysis of sperm DNA fragmentation and measurements of oxidative stress markers provide an independent measure of fertility in men with varicocele. These diagnostic modalities have both diagnostic and prognostic information complementary to, but distinct from conventional sperm parameters. Test results can guide management and aid in monitoring intervention outcomes. Proteomics, metabolomics, and genomics are areas; though still developing, holding promise to revolutionize our understanding of reproductive physiology, including varicocele.

Indexed as

Acrylic ResinsAndrologyHumansInfertility, MaleMalePrognosisSpermatozoaVaricoceleAcrylic ResinsFutur Acryl 2000

Identifiers

PMID26780873
PMCPMC4770487

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.