Evidence map›Paper›PMID 26780781›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2016

Rasmussen's encephalitis: advances in management and patient outcomes.

Caitlin E Hoffman, Ayako Ochi, Orlando Carter Snead, Elysa Widjaja, Cynthia Hawkins, Martin Tisdal, James T Rutka

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. The role of early immunotherapy in rasmussen's encephalitis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  9. Left hemispherectomy in older children and adolescents: outcome of cognitive abilities.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Caitlin E HoffmanDivision of Pediatric Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada. ceh2003@med.cornell.edu.
Ayako OchiDivision of Neurology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Orlando Carter SneadDivision of Neurology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Elysa WidjajaDivision of Diagnostic Imaging, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Cynthia HawkinsDivision of Neuropathology, Hospital for Sick Children, Toronto, ON, Canada.
Martin TisdalDivision of Pediatric Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
James T RutkaDivision of Pediatric Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Hospital for Sick Children · CASickKids Foundation · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRasmussen's encephalitis (RE) is a hemispheric inflammatory disorder resulting in progressive epilepsy, hemiparesis, and cognitive decline. Controversy surrounds the most effective timing of surgery with respect to language dominance, functional status, and seizure outcome. We describe our experience with RE to inform treatment decisions.

methodsA retrospective chart review was performed in children diagnosed with RE from 1983 to 2012.

resultsThirteen consecutive cases were identified: six males and seven females with a mean age of 10.6 years (range 5-18). Nine patients received immunotherapy, with transient benefit in three, treatment-associated complications in two, and no difference in their mean time to treatment (5.38 vs 6.37 years p = 0.74) or long-term outcome. Mean follow-up was 5.6 years (range 0.58-12.25). There was no difference in outcome based on pre-operative duration of seizures. At last follow-up, 63 % of surgically treated patients achieved seizure freedom, 100 % had improved seizure control, 90 % had improved cognitive function, 36 % stopped medication, and 63 % tapered medication. Language improved in 83 % of patients with dominant disease. These findings were not associated with age at treatment. All surgical patients were ambulatory at last follow-up.

conclusionsHemispherotomy achieves good seizure control with cognitive improvement and ambulatory status post-operatively. Time to surgery and dominant disease were not associated with outcome, suggesting that hemispherotomy can be offered early or late, with expectations of good seizure control and functional outcome, even with dominant disease.

Indexed as

Disease ManagementTreatment OutcomeAdolescentChildChild, PreschoolCognition DisordersEncephalitisFemaleFollow-Up StudiesHemispherectomyHumansImmunotherapyMagnetoencephalographyMaleNeuroimagingRetrospective StudiesHemispherotomyImmunotherapyIntractable epilepsyMEG

Identifiers

PMID26780781
OpenAlexW2256619241

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.