ArticleEuropean radiology2016
Increased fractional anisotropy in the motor tracts of Parkinson's disease suggests compensatory neuroplasticity or selective neurodegeneration.
Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- Diffusion tensor imaging in Parkinson's disease: Review and meta-analysis.NeuroImage. Clinical · 2017Pooled it
- Transcranial Pulse Stimulation Enhances Dexterity in Parkinson's Disease: A Randomized Sham-Controlled Trial.Movement disorders : official journal of the Movement Disorder Society · 2026Trial
- Longitudinal quantitative streamline tractography: robust estimation of white matter connectivity differences.bioRxiv : the preprint server for biology · 2026Article
- Diffusion Tensor Tractography Shows White Matter Tract Changes in Breast Cancer Survivors with Balance Impairment.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- Abnormal Magnetic Resonance Imaging in the Medial Prefrontal Cortex following Prenatal Alcohol Exposure and Placental Insufficiency in a Preclinical Model.Developmental neuroscience · 2025Article
- Fractional Anisotropy Alterations in Key White Matter Pathways Associated with Cognitive Performance Assessed by MoCA.Neurology international · 2025Article
- Investigating white matter alterations in Parkinson's disease using multi-shell free-water DTI and NODDI: insights into neurodegeneration and levodopa effects.Frontiers in neurology · 2025Article
- Brain structural MRI marker for predicting conversion to Parkinson's disease in individuals with prodromal symptoms.Frontiers in aging neuroscience · 2025Article
- Encephalography cross-frequency coupling and brain alteration in amyotrophic lateral sclerosis.Brain communications · 2025Article
- Atrophy-related corticospinal changes in advanced Parkinson's disease are associated with the genetic etiology of the disease.Journal of Parkinson's disease · 2024Article
- A worldwide study of white matter microstructural alterations in people living with Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Article
- Analysis of striatal connectivity corresponding to striosomes and matrix in de novo Parkinson's disease and isolated REM behavior disorder.NPJ Parkinson's disease · 2024Article
- Association between Body Mass Index and Brain Health in Adults: A 16-Year Population-Based Cohort and Mendelian Randomization Study.Health data science · 2024Article
- Microstructural alterations in white matter and related neurobiology based on the new clinical subtypes of Parkinson's disease.Frontiers in neuroscience · 2024Article
- Ventral and dorsal aspects of the inferior frontal-occipital fasciculus support verbal semantic access and visually-guided behavioural control.Brain structure & function · 2024Article
- Brain MRI Biomarkers in Isolated Rapid Eye Movement Sleep Behavior Disorder: Where Are We? A Systematic Review.Brain sciences · 2023Review
- Review
- Diffusion Measures of Subcortical Structures Using High-Field MRI.Brain sciences · 2023Article
- Aberrant corticospinal tract characteristics in prodromal PD: A diffusion tensor imaging study.Clinical parkinsonism & related disorders · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo determine the differences in motor pathways and selected non-motor pathways of the basal ganglia in Parkinson's disease (PD) patients compared to healthy controls (HCs).
methodsWe analysed diffusion weighted imaging data of 24 PD patients and 26 HCs. We performed deterministic tractography analysis using the spherical deconvolution-based damped Richardson-Lucy algorithm and subcortical volume analysis.
resultsWe found significantly increased fractional anisotropy (FA) in the motor pathways of PD patients: the bilateral corticospinal tract (right; corrected p = 0.0003, left; corrected p = 0.03), bilateral thalamus-motor cortex tract (right; corrected p = 0.02, left; corrected p = 0.004) and the right supplementary area-putamen tract (corrected p = 0.001). We also found significantly decreased FA in the right uncinate fasiculus (corrected p = 0.01) and no differences of FA in the bilateral supero-lateral medial forebrain bundles (p > 0.05) of PD patients compared to HCs. There were no subcortical volume differences (p > 0.05) between the PD patients and HCs.
conclusionThese results can inform biological models of neurodegeneration and neuroplasticity in PD. We suggest that increased FA values in the motor tracts in PD may reflect compensatory reorganization of neural circuits indicative of adaptive or extended neuroplasticity. KEY POINTS: • Fractional anisotropy was higher in motor pathways of PD patients compared to healthy controls. • Fractional anisotropy was lower in the uncinate fasciculus of PD patients compared to healthy controls. • Increased fractional anisotropy could suggest adaptive neuroplasticity or selective neurodegeneration.
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