ArticleThe Journal of comparative neurology2016
Synaptic circuitry of identified neurons in the antennal lobe of Drosophila melanogaster.
Article in The Journal of comparative neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
- Article
- An integrated anatomical, functional and evolutionary view of the Drosophila olfactory system.EMBO reports · 2025Article
- An integrated anatomical, functional and evolutionary view of thebioRxiv : the preprint server for biology · 2025Article
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- A conditional strategy for cell-type-specific labeling of endogenous excitatory synapses inCell reports methods · 2023Article
- Gustation in insects: taste qualities and types of evidence used to show taste function of specific body parts.Journal of insect science (Online) · 2023Article
- Experience-dependent plasticity in the olfactory system ofFrontiers in cellular neuroscience · 2023Review
- Review
- Genetic regulation of central synapse formation and organization in Drosophila melanogaster.Genetics · 2022Review
- Review
- Article
- Antennal-lobe neurons in the moth Helicoverpa armigera: Morphological features of projection neurons, local interneurons, and centrifugal neurons.The Journal of comparative neurology · 2021Article
- Article
- BAcTrace, a tool for retrograde tracing of neuronal circuits in Drosophila.Nature methods · 2020Article
- Wiring patterns from auditory sensory neurons to the escape and song-relay pathways in fruit flies.The Journal of comparative neurology · 2020Article
- Muscarinic Modulation of Antennal Lobe GABAergic Local Neurons Shapes Odor Coding and Behavior.Cell reports · 2019Article
- Neurogenetic dissection of theeLife · 2019Article
- A resource for theeLife · 2018Article
- Sexual dimorphism in visual and olfactory brain centers in the perfume-collecting orchid bee Euglossa dilemma (Hymenoptera, Apidae).The Journal of comparative neurology · 2018Article
- Three-Dimensional Portable Document Format (3D PDF) in Clinical Communication and Biomedical Sciences: Systematic Review of Applications, Tools, and Protocols.JMIR medical informatics · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila melanogaster olfactory sensory neurons (OSNs) establish synapses with projection neurons (PNs) and local interneurons within antennal lobe (AL) glomeruli. Substantial knowledge regarding this circuitry has been obtained by functional studies, whereas ultrastructural evidence of synaptic contacts is scarce. To fill this gap, we studied serial sections of three glomeruli using electron microscopy. Ectopic expression of a membrane-bound peroxidase allowed us to map synaptic sites along PN dendrites. Our data prove for the first time that each of the three major types of AL neurons is both pre- and postsynaptic to the other two types, as previously indicated by functional studies. PN dendrites carry a large proportion of output synapses, with approximately one output per every three input synapses. Detailed reconstructions of PN dendrites showed that these synapses are distributed unevenly, with input and output sites partially segregated along a proximal-distal gradient and the thinnest branches carrying solely input synapses. Moreover, our data indicate synapse clustering, as we found evidence of dendritic tiling of PN dendrites. PN output synapses exhibited T-shaped presynaptic densities, mostly arranged as tetrads. In contrast, output synapses from putative OSNs showed elongated presynaptic densities in which the T-bar platform was supported by several pedestals and contacted as many as 20 postsynaptic profiles. We also discovered synaptic contacts between the putative OSNs. The average synaptic density in the glomerular neuropil was about two synapses/µm(3) . These results are discussed with regard to current models of olfactory glomerular microcircuits across species.
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