ArticleClinical rheumatology2016
Is blood neutrophil-lymphocyte ratio an independent predictor of knee osteoarthritis severity?
Article in Clinical rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 72 citations in OpenAlex.
- Circulating sTLR4 and sTREM-1 in Knee Osteoarthritis: Associations with Study-Specific MRI-Defined Categories and Disease Burden.Journal of clinical medicine · 2026Article
- Red blood cell distribution width-to-albumin ratio and osteoarthritis: A cross-sectional and cohort study.The Journal of international medical research · 2026Article
- The effects of ultrasound-guided genicular nerve block on proprioception and static balance in knee osteoarthritis patients.Turkish journal of physical medicine and rehabilitation · 2026Article
- Phenotypic Differences in Inflammatory, Metabolic, and Biochemical Biomarkers in Dogs with Osteoarthritis According to Body Condition and Sex.Animals : an open access journal from MDPI · 2026Article
- Inflammation in osteonecrosis of the femoral head: Evaluation of hematological biomarkers and potential prognostic value.PloS one · 2026Article
- The Association Between Platelet Indices and Osteoarthritis: A Systematic Review and Meta-analysis.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2026Article
- Association between neutrophil-lymphocyte ratio and all-cause and cardiovascular mortality in osteoarthritis patients from the NHANES 1999-2018 cohort.Scientific reports · 2025Article
- Neutrophil-to-Lymphocyte Ratio as a Marker for Postoperative Stress in Robot-Assisted Total Knee Arthroplasty.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Can We Determine Osteoarthritis Severity Based on Systemic Immuno-Inflammatory Index?Diagnostics (Basel, Switzerland) · 2025Article
- Role of neutrophil to lymphocyte ratio in osteoarthritis: A systematic review and meta-analysis.World journal of orthopedics · 2025Article
- Is there a relationship between blood inflammation markers and the severity of knee osteoarthritis?Turkish journal of physical medicine and rehabilitation · 2025Article
- Association of peripheral inflammatory indicators with osteoarthritis risk.Osteoarthritis and cartilage open · 2024Article
- Inflammatory burden index: associations between osteoarthritis and all-cause mortality among individuals with osteoarthritis.BMC public health · 2024Article
- Combination of Curcuminoids and Acupressure for Inflammation and Pain in Older People with Osteoarthritis Genu: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2024Article
- Synovial fluid monocyte-to-lymphocyte ratio in knee osteoarthritis patients predicts patient response to conservative treatment: a retrospective cohort study.BMC musculoskeletal disorders · 2024Article
- Eosinophil-to-Lymphocyte Ratio and Eosinophil Count as New Predictive Markers for Osteoarthritis.Journal of pain research · 2024Article
- Individual immune cell and cytokine profiles determine platelet-rich plasma composition.Arthritis research & therapy · 2023Article
- Article
- Are inflammatory parameters an independent predictor of hip osteoarthritis severity? A prospective cross-sectional study.Revista da Associacao Medica Brasileira (1992) · 2022Article
- A Simple Nomogram for Predicting Osteoarthritis Severity in Patients with Knee Osteoarthritis.Computational and mathematical methods in medicine · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knee osteoarthritis (OA) is one of the most common forms of joint disease, affecting an increasing number of people worldwide. Latest data suggests that inflammation plays a critical role in the pathogenesis of OA. There are a number of inflammatory markers like cytokins and cartilage degradation products that can be used as indicators in OA. Blood neutrophil-lymphocyte ratio (NLR) is a simple non-invasive and cost-effective marker of inflammation in various systemic diseases, but it has not been investigated in OA yet. The aim of the present study was to compare blood NLR levels in patients with severe - Kellgren and Lawrence (KL) grade 4 - knee OA and mild to moderate - KL grades 1-3 - knee OA. A total of 176 patients with knee OA were included in this cross-sectional study. KL grading was done according to the two-view (antero-posterior and lateral) plain radiography of both knees. Demographic characteristics, blood neutrophil, lymphocyte and platelet counts, erythrocyte sedimentation rate, and C-reactive protein were recorded. Blood NLR levels were calculated. In the severe knee OA group, blood NLR levels were found to be elevated as compared to the mild to moderate knee OA group. A blood NLR of ≥2.1 was taken as the cutoff based upon the receiver operating characteristics (roc). In the roc curve analysis, blood NLR ≥ 2.1 had 50 % sensitivity and 77 % specificity in predicting severe knee OA. In multivariate analysis, age and blood NLR ≥ 2.1 emerged as independent predictors of severe knee OA. The results of the present study, for the first time in the literature, suggests blood NLR as a novel and promising inflammatory marker indicating the severity of knee OA.
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