ArticleInvestigative ophthalmology & visual science2016
Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Targeting AKT via SC79 for Photoreceptor Preservation in Retinitis Pigmentosa Mouse Models.Biomedicines · 2026Article
- Amine-responsive Rhodopsin-like GPCRs in ocular pathology: mechanistic associations, candidate biomarkers, and therapeutic potential.Frontiers in physiology · 2026Review
- Lack of strong evidence for cone photoreceptors' contribution to human melatonin suppression and alerting response to light.iScience · 2025Article
- Melatonin and retinal cell damage: molecular and biological functions.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- The Role and Therapeutic Potential of Melatonin in Degenerative Fundus Diseases: Diabetes Retinopathy and Age-Related Macular Degeneration.Drug design, development and therapy · 2024Review
- Effects of circadian rhythm disruption on retinal physiopathology: Considerations from a consensus of experts.European journal of ophthalmology · 2022Article
- Melatonin Receptors: A Key Mediator in Animal Reproduction.Veterinary sciences · 2022Review
- Circadian Regulation of Retinal Pigment Epithelium Function.International journal of molecular sciences · 2022Review
- The Role of the Melatoninergic System in Circadian and Seasonal Rhythms-Insights From Different Mouse Strains.Frontiers in physiology · 2022Review
- Intravitreous delivery of melatonin affects the retinal neuron survival and visual signal transmission:Drug delivery · 2020Article
- CRISPR/Cas9 mediated mutation of the mtnr1a melatonin receptor gene causes rod photoreceptor degeneration in developing Xenopus tropicalis.Scientific reports · 2020Article
- Review
- Intravitreal Delivery of Melatonin Is Protective Against the Photoreceptor Loss in Mice: A Potential Therapeutic Strategy for Degenerative Retinopathy.Frontiers in pharmacology · 2019Article
- Melatonin receptor heterodimerization in a photoreceptor-like cell line endogenously expressing melatonin receptors.Molecular vision · 2019Article
- Removal of clock geneProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Heteromeric MTExperimental eye research · 2018Article
- Ocular Clocks: Adapting Mechanisms for Eye Functions and Health.Investigative ophthalmology & visual science · 2018Review
- Melatonin receptors: molecular pharmacology and signalling in the context of system bias.British journal of pharmacology · 2018Review
- Aging Alters Circadian Rhythms in the Mouse Eye.Journal of biological rhythms · 2018Article
- Melatonin signaling affects the timing in the daily rhythm of phagocytic activity by the retinal pigment epithelium.Experimental eye research · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
purposePrevious studies have demonstrated that melatonin has an important role in the modulation of photoreceptor viability during aging and may be involved in the pathogenesis of age-related macular degeneration.This hormone exerts its influence by binding to G-protein coupled receptors named melatonin receptor 1 (MT1) and 2 (MT2). Melatonin receptors 1 and 2 activate a wide variety of signaling pathways.
methodsMelatonin-proficient mice (C3H/f+/+) and melatonin-proficient mice lacking MT1 or MT2 receptors (MT1-/- and MT2-/-) were used in this study. Mice were killed at the ages of 3 and 18 months, and photoreceptor viability was determined by counting nuclei number in the outer nuclear layer (ONL). Cones were identified by immunohistochemistry using peanut agglutinin (PNA) and green/red and blue opsin antibodies. Protein kinase B (AKT) and forkhead box O (FOXO1) were assessed by Western blotting and immunohistochemistry.
resultsThe number of nuclei in the ONL was significantly reduced in C3Hf+/+, MT1-/-, and MT2-/- mice at 18 months of age with respect to 3-month-old animals. In 18-month-old MT1-/- and MT2-/- mice, but not in C3H/f+/+, the number of cones was significantly reduced with respect to young MT1-/- and MT2-/- mice or age-matched C3H/f+/+. In C3H/f+/+, activation of the AKT-FOXO1 pathway in the photoreceptors showed a significant difference between night and day.
conclusionsOur data indicate that disruption of MT1/MT2 heteromer signaling induces a reduction in the number of photoreceptors during aging and also suggest that the AKT-FOXO1 survival pathway may be involved in the mechanism by which melatonin protects photoreceptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.