ReviewOral and maxillofacial surgery2016
Cutaneous squamous cell carcinoma of the scalp in the immunocompromised patient: review of 53 cases.
Review in Oral and maxillofacial surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- riSCC: A personalized risk model for the development of poor outcomes in cutaneous squamous cell carcinoma.Journal of the American Academy of Dermatology · 2025Article
- Predicting adjuvant radiation therapy benefit in cutaneous squamous cell carcinoma with the 40-gene expression profile.Future oncology (London, England) · 2024Article
- The Utility of Bone Burring for the Clearance of Locally Advanced Scalp Malignancies: A Scoping Review.Plastic and reconstructive surgery. Global open · 2023Article
- Management of Cutaneous Head and Neck Squamous and Basal Cell Carcinomas for Immunocompromised Patients.Cancers · 2023Review
- Review
- Invasive cutaneous squamous cell carcinoma of scalp: A case report.Annals of medicine and surgery (2012) · 2022Article
- Review
- Assessing the accuracy of computed tomography in detecting bony invasion and thickness of squamous cell carcinoma of the scalp.The neuroradiology journal · 2021Article
- Review
- Squamous cell carcinoma of the scalp causing cortical venous thrombosis and Intraparenchymal hematoma.eNeurologicalSci · 2020Article
- Management of a recurrence of a squamous cell carcinoma of the scalp with extension to the brain: A case report and literature review.Surgical neurology international · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe analyzed outcomes from immunocompromised patients with scalp squamous cell carcinoma (SCC) treated with surgical excision with and without radiation in order to explore 3-year disease-free survival and overall survival. STUDY
designThe study design was a retrospective chart review.
settingThis study was conducted in a private practice setting. SUBJECTS AND
methodsThe study included 53 immunocompromised patients with an average age of 63.2 years, with scalp squamous cell carcinoma. Pre-operative imaging dictated the extent of resection. Patients with bony involvement received wide local excision including full-thickness craniectomy and cranioplasty. Patients without bony involvement underwent wide local excision and outer-table calvarial resection. All patients were recommended to have post-operative radiation. Patients were followed for a minimum of 3 years.
resultsA total of 53 patients were included in the study. Six patients had pre-operative CT showing bone involvement and were treated with full-thickness craniectomy along with post-operative radiation. Fourteen patients without bone involvement on pre-operative CT were found to have positive bone involvement on final pathology. Forty-five patients underwent post-operative radiation. Patients treated with adjuvant radiation demonstrated a 3-year survival of 80 % and the overall survival was 62 %. In the surgery-only group, the 3-year survival was 62.5 % and the overall survival was 32.5 %.
conclusionsImmunocompromised patients with scalp SCC have a poor prognosis. Early detection and treatment are crucial. Based on our results, we recommend wide local excision with at least outer-table calvarial resection, and post-operative radiation. Despite aggressive therapy, patients may still have distant, local, or regional recurrence. LEVEL OF EVIDENCE: level 2b (retrospective cohort).
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