ArticleeLife2016
The magnesium transporter A is activated by cardiolipin and is highly sensitive to free magnesium in vitro.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Membrane Mimetics Control Internal Hydration and Catalytic Activity of the Copper ATPase LpCopA fromInternational journal of molecular sciences · 2026Article
- Distinctive Lacritin Cleavage-Potentiated Bactericidal Alteration of thebioRxiv : the preprint server for biology · 2026Article
- Structural and mutational insights define ERMA as the ER MgScience advances · 2026Article
- Distinct transport cycle and lipid regulation of a MgResearch square · 2026Article
- Magnesium Transporters as Crucial Regulators of Bacterial Survival and Pathogenicity.Microorganisms · 2026Review
- ARNA (New York, N.Y.) · 2026Article
- P-type ATPase magnesium transporter MgtA acts as a dimer.Nature structural & molecular biology · 2025Article
- High-Throughput Tn-Seq Screens Identify Both Known and Novel Pseudomonas putida KT2440 Genes Involved in Metal Tolerance.Environmental microbiology · 2025Article
- An updated overview on the bacterial PhoP/PhoQ two-component signal transduction system.Frontiers in cellular and infection microbiology · 2025Review
- ERMA (TMEM94) is a P-type ATPase transporter for MgMolecular cell · 2024Article
- Flipping the switch: dynamic modulation of membrane transporter activity in bacteria.Microbiology (Reading, England) · 2023Review
- Lactiplantibacillus plantarum as a novel platform for production and purification of integral membrane proteins using RseP as the benchmark.Scientific reports · 2023Article
- A bioinformatic analysis of zinc transporters in intestinal Lactobacillaceae.Metallomics : integrated biometal science · 2023Article
- Reconsidering theACS bio & med chem Au · 2022Article
- Microbial Inoculation Improves Growth, Nutritional and Physiological Aspects ofMicroorganisms · 2022Article
- Iron-responsive riboswitches.Current opinion in chemical biology · 2022Review
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- Molecular dynamics simulations of the adsorption of an intrinsically disordered protein: Force field and water model evaluation in comparison with experiments.Frontiers in molecular biosciences · 2022Article
- Synergetic Inactivation Mechanism of Protocatechuic Acid and High Hydrostatic Pressure againstFoods (Basel, Switzerland) · 2021Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The magnesium transporter A (MgtA) is a specialized P-type ATPase, believed to import Mg(2+) into the cytoplasm. In Salmonella typhimurium and Escherichia coli, the virulence determining two-component system PhoQ/PhoP regulates the transcription of mgtA gene by sensing Mg(2+) concentrations in the periplasm. However, the factors that affect MgtA function are not known. This study demonstrates, for the first time, that MgtA is highly dependent on anionic phospholipids and in particular, cardiolipin. Colocalization studies confirm that MgtA is found in the cardiolipin lipid domains in the membrane. The head group of cardiolipin plays major role in activation of MgtA suggesting that cardiolipin may act as a Mg(2+) chaperone for MgtA. We further show that MgtA is highly sensitive to free Mg(2+) (Mg(2+)free) levels in the solution. MgtA is activated when the Mg(2+)free concentration is reduced below 10 μM and is strongly inhibited above 1 mM, indicating that Mg(2+)free acts as product inhibitor. Combined, our findings conclude that MgtA may act as a sensor as well as a transporter of Mg(2+).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.