ArticleNeuroscience bulletin2016
Actin Aggregations Mark the Sites of Neurite Initiation.
Article in Neuroscience bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Role of olfactory receptor Olfr544 in neuronal cells: Insights into neurite outgrowth and CREB signaling.iScience · 2026Article
- Gαi2 promotes microtubule-driven incorporation of neurofilaments to stabilise nascent axons in vivo.EMBO reports · 2026Article
- Mitigation of synaptic and memory impairments via F-actin stabilization in Alzheimer's disease.Alzheimer's research & therapy · 2024Article
- Unraveling NEK4 as a Potential Drug Target in Schizophrenia and Bipolar I Disorder: A Proteomic and Genomic Approach.Schizophrenia bulletin · 2024Article
- The cytoplasmic localization of ADNP through 14-3-3 promotes sex-dependent neuronal morphogenesis, cortical connectivity, and calcium signaling.Molecular psychiatry · 2023Article
- Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo.EMBO reports · 2022Article
- Establishing neuronal polarity: microtubule regulation during neurite initiation.Oxford open neuroscience · 2022Review
- Protein kinases: master regulators of neuritogenesis and therapeutic targets for axon regeneration.Cellular and molecular life sciences : CMLS · 2020Review
- Gamma oscillations in the pedunculopontine nucleus are regulated by F-actin: neuroepigenetic implications.American journal of physiology. Cell physiology · 2020Article
- AutoNeuriteJ: An ImageJ plugin for measurement and classification of neuritic extensions.PloS one · 2020Article
- Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders.Scientific reports · 2019Article
- Endocytic Adaptor Protein HIP1R Controls Intracellular Trafficking of Epidermal Growth Factor Receptor in Neuronal Dendritic Development.Frontiers in molecular neuroscience · 2018Article
- Phosphatidylinositol 3,4-bisphosphate regulates neurite initiation and dendrite morphogenesis via actin aggregation.Cell research · 2017Article
- Overexpression of Tau Rescues Nogo-66-Induced Neurite Outgrowth Inhibition In Vitro.Neuroscience bulletin · 2016Article
- Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A salient feature of neurons is their intrinsic ability to grow and extend neurites, even in the absence of external cues. Compared to the later stages of neuronal development, such as neuronal polarization and dendrite morphogenesis, the early steps of neuritogenesis remain relatively unexplored. Here we showed that redistribution of cortical actin into large aggregates preceded neuritogenesis and determined the site of neurite initiation. Enhancing actin polymerization by jasplakinolide treatment effectively blocked actin redistribution and neurite initiation, while treatment with the actin depolymerizing agents latrunculin A or cytochalasin D accelerated neurite formation. Together, these results demonstrate a critical role of actin dynamics and reorganization in neurite initiation. Further experiments showed that microtubule dynamics and protein synthesis are not required for neurite initiation, but are required for later neurite stabilization. The redistribution of actin during early neuronal development was also observed in the cerebral cortex and hippocampus in vivo.
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