Evidence map›Paper›PMID 26779904›Full record

SynthesisSleep & breathing = Schlaf & Atmung2016

Obstructive sleep apnoea and risks of all-cause mortality: preliminary evidence from prospective cohort studies.

Lei Pan, Xiaomei Xie, Dayue Liu, Dunqiang Ren, Yongzhong Guo

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Sleep & breathing = Schlaf & Atmung, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lei PanDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, China.
Xiaomei XieDepartment of Radiotherapy, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou, Jiangsu, 221009, China.
Dayue LiuDepartment of Respiratory Medicine, XuZhou Central Hospital, The Affiliated XuZhou Hospital of Medical College of Southeast University, 199 South Jiefang Road, Xuzhou, Jiangsu, 221009, China.
Dunqiang RenDepartment of Respiratory Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China.
Yongzhong GuoDepartment of Respiratory Medicine, XuZhou Central Hospital, The Affiliated XuZhou Hospital of Medical College of Southeast University, 199 South Jiefang Road, Xuzhou, Jiangsu, 221009, China. yongzhguo@sina.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA meta-analysis of prospective cohort studies was conducted to clarify the association between obstructive sleep apnoea (OSA) and future risk of all-cause mortality.

methodsEligible studies were identified by searching the PubMed and EMBASE databases up to July 2015. Pooled hazard ratios (HRs) and their corresponding 95 % confidence intervals (CIs) were calculated to estimate the association between OSA and risk of all-cause mortality. Sources of heterogeneity were identified by subgroup and meta-regression analyses.

resultsTwelve prospective cohort studies involving 34,382 participants were included in this meta-analysis. The pooled HR of all-cause mortality was 1.262 (95 % CI 1.093-1.431) with significant heterogeneity. Subgroup analyses indicated that the pooled HRs of all-cause mortality in patients with mild, moderate and severe OSA were 0.945 (95 % CI 0.810-1.081), 1.178 (95 % CI 0.978-1.378) and 1.601 (95 % CI 1.298-1.902), respectively. OSA severity could be a possible sources of heterogeneity. Existing publication bias produced a minor contribution to effect size.

conclusionSevere, but not mild to moderate, OSA is significantly associated with increased risk of all-cause mortality.

Indexed as

Cause of DeathCohort StudiesHumansProportional Hazards ModelsProspective StudiesRisk AssessmentSleep Apnea, ObstructiveAll-cause mortalityMeta-analysisObstructive sleep apnoea

Identifiers

PMID26779904

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.