Evidence map›Paper›PMID 26779902›Full record

ArticleSleep & breathing = Schlaf & Atmung2016

Tooth loss and obstructive sleep apnea signs and symptoms in the US population.

Anne E Sanders, Aderonke A Akinkugbe, Gary D Slade, Greg K Essick

Abstract read
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Association of edentulism and obstructive sleep apnea: A systematic review.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2025
    Pooled it
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  5. Trial
  6. Linking disease severity and mortality in obstructive sleep apnea: the role of the endothelial activation and stress index.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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  15. Sleep and periodontal health.Periodontology 2000 · 2024
    Review
  16. Article
  17. Review
  18. Sleep apnea pathophysiology.Sleep & breathing = Schlaf & Atmung · 2023
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anne E SandersDepartment of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, 385 S. Columbia Street, Room 4502, Chapel Hill, NC, 27599-7455, USA. anne_sanders@unc.edu.
Aderonke A AkinkugbeDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Gary D SladeDepartment of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, 385 S. Columbia Street, Room 4502, Chapel Hill, NC, 27599-7455, USA.
Greg K EssickDepartment of Prosthodontics and Center for Pain Research and Innovation, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7455, USA.
University of North Carolina at Chapel Hill · US

Funding

Training Program for the Next Generation of Oral Health Researchers (NextGen)T90DE021986 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EVERETT, ERIC T. · 2011 to 2017
$2.3M
Training Program for the Next Generation of Oral Health Researches (NextGen)R90DE022527 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EVERETT, ERIC T. · 2011 to 2016
$672k
NIDCR NIH HHS R90 DE022527NIDCR NIH HHS T90 DE021986
6 · The paper itself

Abstract

purposeThe aim of this study is to investigate the relationship between tooth loss and signs and symptoms of obstructive sleep apnea (OSA) in a representative sample of the general US population.

methodsData were from 7305 men and women aged ≥25 years participating in the 2005-2008 National Health and Nutrition Examination Survey. Tooth loss, occlusal contacts, and denture use were determined by dental examination. Four cardinal OSA signs and symptoms were evaluated by questions based on American Academy of Sleep Medicine criteria. Adults with ≥2 signs/symptoms of OSA were classified at high-risk of OSA. Prevalence ratios (PR) and 95 % confidence limits (CL) from log binomial regression models estimated the strength of association between tooth loss and high-risk for OSA, adjusting for demographic characteristics, body mass index, dentures, and sleep duration.

resultsPrevalence of high-risk for OSA increased 2 % for each additional lost tooth (PR = 1.02, 95 % CL, 1.01, 1.03) among adults aged 25 to 65 years. When tooth loss was modeled as an ordinal variable with 0-4 lost teeth as the referent category, adjusted prevalence of high-risk for OSA was as follows: 25 % greater in those missing 5-8 teeth (PR = 1.25, 95 % CL, 1.07, 1.46); 36 % greater in those missing 9-31 teeth (PR = 1.36, 95 % CL, 1.06, 1.73); and 61 % greater in the edentulous (PR = 1.61, 95 % CL, 1.11, 2.33).

conclusionTooth loss may be an independent risk factor for OSA.

Indexed as

AdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedMouth, EdentulousNutrition SurveysRiskSleep Apnea, ObstructiveStatistics as TopicSurveys and QuestionnairesTooth LossEpidemiologyNHANESOral healthPopulationSleep-disordered breathingTooth loss

Identifiers

PMID26779902
PMCPMC4947024
OpenAlexW2283995071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.