ArticleNature materials2016
Energy landscapes and functions of supramolecular systems.
Article in Nature materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
107 citing papers in PubMed, 1 synthesis or guideline pooled it, 451 citations in OpenAlex.
- Advances in Dynamic/Adaptive Supramolecular Self-Assembly: From Molecular Design to Stimuli-Responsive Control.Macromolecular rapid communications · 2026Pooled it
- Reversible self-assembly of small molecules for recyclable solid-state battery electrolytes.Nature chemistry · 2026Article
- Nonionic peptide amphiphiles and their supramolecular co-assemblies tune charge density and bioactivity.Journal of materials chemistry. B · 2026Article
- Out-of-Equilibrium Supramolecular Assembly Sustained by Photocatalysis.Angewandte Chemie (International ed. in English) · 2026Article
- Biomimetic peptide self-assembly: interfacing with biomacromolecules to regulate cellular signaling.Experimental & molecular medicine · 2026Review
- Programming Hydrogel Mechanics via Sequence-Controlled Polymerization Using Peptide Self-Assembly.Journal of the American Chemical Society · 2026Article
- Elucidating β-Sheet Ordering in Lipopeptides Bearing Lysine-Rich Tripeptide Sequences: Fibrils versus Nanotapes.The journal of physical chemistry. B · 2026Article
- Peptide Amphiphiles Hitchhike on Endogenous Biomolecules for Enhanced Cancer Imaging and Therapy.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Toward development of a dynamic supramolecular peptide therapy for acute ischemic stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Evolving Data-Driven Strategies for the Characterization of Supramolecular Polymers and Systems.Angewandte Chemie (International ed. in English) · 2025Review
- Dynamic pathways in energy landscapes guiding supramolecular Janus dendrimer self-assemblies between lamellar and cubic architectures.Nature communications · 2025Article
- Merging Natural Biopolymers with Supramolecular Chemistry: Emulating the Native Extracellular Matrix's Complexity.ACS nano · 2025Review
- Drug-Inspired Design of Supramolecular Polymers for Enhanced Drug Loading and Sustained Therapeutic Release.ACS nano · 2025Article
- Tuning the Supramolecular Polymerization and Cell Response of Ureidopyrimidinone Monomers by Pushing the Hydrophobic Threshold.Journal of the American Chemical Society · 2025Article
- Hybrid pH Responsive Supramolecular Polymers Through the Combination of the Ureido-Pyrimidinone Motif with β-Sheet Peptide Sequences.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Supramolecular Gels with Potential Applications as Anti-Icing Agents.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Mapping in situ the assembly and dynamics in aqueous supramolecular polymers.Nature communications · 2025Article
- Tuning the Dimensionality of Protein-Peptide Coassemblies to Build 2D Conductive Nanomaterials.ACS nano · 2025Article
- Photoactuating artificial muscle from supramolecular assembly of an overcrowded alkene-derived molecular switch.Nature communications · 2025Article
- ATP-Regulated Formation of Transient Peptide Amphiphiles Superstructures.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 3 countries.
Funding
Abstract
By means of two supramolecular systems--peptide amphiphiles engaged in hydrogen-bonded β-sheets, and chromophore amphiphiles driven to assemble by π-orbital overlaps--we show that the minima in the energy landscapes of supramolecular systems are defined by electrostatic repulsion and the ability of the dominant attractive forces to trap molecules in thermodynamically unfavourable configurations. These competing interactions can be selectively switched on and off, with the order of doing so determining the position of the final product in the energy landscape. Within the same energy landscape, the peptide-amphiphile system forms a thermodynamically favoured product characterized by long bundled fibres that promote biological cell adhesion and survival, and a metastable product characterized by short monodisperse fibres that interfere with adhesion and can lead to cell death. Our findings suggest that, in supramolecular systems, functions and energy landscapes are linked, superseding the more traditional connection between molecular design and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.