ArticleLaboratory investigation; a journal of technical methods and pathology2016
Spectrally encoded confocal microscopy for diagnosing breast cancer in excision and margin specimens.
Article in Laboratory investigation; a journal of technical methods and pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Label-free subcellular imaging with dynamic spectrally encoded confocal microscopy (D-SECM) with subpixel jitter correction.Biomedical optics express · 2026Article
- Effective transfer of tumor annotations from hematoxylin and eosin to fluorescence images of breast and lung tissues.Journal of biomedical optics · 2026Article
- Article
- Deep learning-enabled realistic virtual histology with ultraviolet photoacoustic remote sensing microscopy.Nature communications · 2023Article
- Volumetric High-Resolution X-Ray Phase-Contrast Virtual Histology of Breast Specimens With a Compact Laboratory System.IEEE transactions on medical imaging · 2022Article
- Is Real-Time Microscopy on the Horizon? A Brief Review of the Potential Future Directions in Clinical Breast Tumor Microscopy Implementation.Virchows Archiv : an international journal of pathology · 2022Review
- High-Throughput, Label-Free and Slide-Free Histological Imaging by Computational Microscopy and Unsupervised Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Development of intraoperative assessment of margins in breast conserving surgery: a narrative review.Gland surgery · 2022Review
- Scattering-Based Light-Sheet Microscopy for Rapid Cellular Imaging of Fresh Tissue.Lasers in surgery and medicine · 2021Article
- Feasibility Study of a Novel Protease-Activated Fluorescent Imaging System for Real-Time, Intraoperative Detection of Residual Breast Cancer in Breast Conserving Surgery.Annals of surgical oncology · 2020Article
- Raman Spectroscopy for Rapid Evaluation of Surgical Margins during Breast Cancer Lumpectomy.Scientific reports · 2019Article
- Rapid pathology of lumpectomy margins with open-top light-sheet (OTLS) microscopy.Biomedical optics express · 2019Article
- Microscopy with ultraviolet surface excitation for wide-area pathology of breast surgical margins.Journal of biomedical optics · 2019Article
- Clinical feasibility of optical coherence micro-elastography for imaging tumor margins in breast-conserving surgery.Biomedical optics express · 2018Article
- Real-time, intraoperative detection of residual breast cancer in lumpectomy cavity walls using a novel cathepsin-activated fluorescent imaging system.Breast cancer research and treatment · 2018Article
- Intra-operative spectroscopic assessment of surgical margins during breast conserving surgery.Breast cancer research : BCR · 2018Article
- Multiscale nonlinear microscopy and widefield white light imaging enables rapid histological imaging of surgical specimen margins.Biomedical optics express · 2018Article
- Rinsing paired-agent model (RPAM) to quantify cell-surface receptor concentrations in topical staining applications of thick tissues.Physics in medicine and biology · 2017Article
- Direct comparison between confocal and multiphoton microscopy for rapid histopathological evaluation of unfixed human breast tissue.Journal of biomedical optics · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
A large percentage of breast cancer patients treated with breast conserving surgery need to undergo multiple surgeries due to positive margins found during post-operative margin assessment. Carcinomas could be removed completely during the initial surgery and additional surgery avoided if positive margins can be determined intraoperatively. Spectrally encoded confocal microscopy (SECM) is a high-speed reflectance confocal microscopy technology that has a potential to rapidly image the entire surgical margin at subcellular resolution and accurately determine margin status intraoperatively. In this study, in order to test the feasibility of using SECM for intraoperative margin assessment, we have evaluated the diagnostic accuracy of SECM for detecting various types of breast cancers. Forty-six surgically removed breast specimens were imaged with an SECM system. Side-by-side comparison between SECM and histologic images showed that SECM images can visualize key histomorphologic patterns of normal/benign and malignant breast tissues. Small (500 μm × 500 μm) spatially registered SECM and histologic images (n=124 for each) were diagnosed independently by three pathologists with expertise in breast pathology. Diagnostic accuracy of SECM for determining malignant tissues was high, average sensitivity of 0.91, specificity of 0.93, positive predictive value of 0.95, and negative predictive value of 0.87. Intra-observer agreement and inter-observer agreement for SECM were also high, 0.87 and 0.84, respectively. Results from this study suggest that SECM may be developed into an intraoperative margin assessment tool for guiding breast cancer excisions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.