ArticleJournal of cardiac failure2016
Transplantation of Center for Disease Control "High-Risk" Donor Hearts Does Not Adversely Impact Long-Term Outcomes in Adults.
Article in Journal of cardiac failure, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- Reasons for donor heart offer refusal in the United States: Results from 14,132 transplant clinician surveys in the Donor Heart Study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Observational
- Reasons for donor heart offer refusal are often unrelated to the donor itself - when, why, and the "weekend effect".The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Observational
- Revolutionizing Donor Heart Procurement: Innovations and Future Directions for Enhanced Transplantation Outcomes.Journal of cardiovascular development and disease · 2024Review
- Association of Donors With US Public Health Service Risk Criteria and Outcomes After Adult vs Pediatric Cardiac Transplant.JAMA cardiology · 2022Article
- Donor Utilization in the Recent Era: Effect of Sex, Drugs, and Increased Risk.Circulation. Heart failure · 2022Article
- Donor Characteristics and Recipient Outcomes After Heart Transplantation in Adult Congenital Heart Disease.Journal of the American Heart Association · 2021Article
- Using machine learning to estimate survival curves for patients receiving an increased risk for disease transmission heart, liver, or lung versus waiting for a standard organ.Transplant infectious disease : an official journal of the Transplantation Society · 2019Article
- How to obtain and maintain favorable results after heart transplantation: keys to success?Annals of cardiothoracic surgery · 2018Article
- The brain-dead donor: An anaesthesiologist's perspective.Indian journal of anaesthesia · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe "high-risk donor" (HRD) label was applied to donors who met the Centers for Disease Control and Prevention criteria for high-risk behavior in 2004. The number of potential recipients who die awaiting orthotopic heart transplantation (OHT) has increased. Despite organ shortages, HRD grafts are often declined given infectious concerns. We hypothesized that recipients would have equivalent outcomes.
methodsWe retrospectively analyzed the United Network of Organ Sharing adult heart transplant data from June 2004 to December 2013. OHT recipients were divided into 2 cohorts by donor status.
resultsDuring the study period, 37,408 OHTs were performed and 3196 (8.5%) patients received HRD grafts. Recipients of HRD were significantly older (P < .0001) and had a higher body mass index (P < .0001) compared with standard-risk donor recipients. No significant difference in waitlist time (P = .69) or blood type (P = .07) was noted. A higher number of HRD recipients were on mechanical circulatory support (35.6%) compared with standard-risk donor (33.3%, P = .009). Both grafts manifested similar, low rates of rejection before discharge (P = .88). One1 (84.3 vs 83%) and 5-year (71.2 vs 65.5%) survival was similar in the cohorts (log-rank P = .7571).
conclusionsHRD status does not significantly affect recipient outcomes after OHT. Increased use of HRD grafts could augment donor pool and decrease the mortality associated with long waitlist times.
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