Evidence map›Paper›PMID 26779631›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

Combination of platelet count and mean platelet volume (COP-MPV) predicts postoperative prognosis in both resectable early and advanced stage esophageal squamous cell cancer patients.

Fan Zhang, Zhaoli Chen, Pan Wang, Xueda Hu, Yibo Gao, Jie He

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 6 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 6 syntheses or guidelines pooled it, 103 citations in OpenAlex.

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  8. Patients Undergoing Oesophageal Cancer Surgery Do Not Have Impaired Haemostasis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fan ZhangNational Cancer Center, Cancer Hospital and Institute, Chinese Academy of Medical Sciences, Panjiayuannanli 17, Chaoyang District, Beijing, 100021, China.
Zhaoli ChenNational Cancer Center, Cancer Hospital and Institute, Chinese Academy of Medical Sciences, Panjiayuannanli 17, Chaoyang District, Beijing, 100021, China.
Pan WangNational Cancer Center, Cancer Hospital and Institute, Chinese Academy of Medical Sciences, Panjiayuannanli 17, Chaoyang District, Beijing, 100021, China.
Xueda HuNational Cancer Center, Cancer Hospital and Institute, Chinese Academy of Medical Sciences, Panjiayuannanli 17, Chaoyang District, Beijing, 100021, China.
Yibo GaoNational Cancer Center, Cancer Hospital and Institute, Chinese Academy of Medical Sciences, Panjiayuannanli 17, Chaoyang District, Beijing, 100021, China.
Jie HeNational Cancer Center, Cancer Hospital and Institute, Chinese Academy of Medical Sciences, Panjiayuannanli 17, Chaoyang District, Beijing, 100021, China. prof.hejie@263.net.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study is to search the most powerful prognostic factor from routine blood test for esophageal squamous cell cancer (ESCC) patients. Multiple laboratory tests were evaluated including those reflecting red blood cell parameters (hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and red blood cell distribution width (RDW)), platelet morphological parameters (mean platelet volume (MPV) and platelet count (PLT)), blood coagulation status (D-dimer), and tumor biomarker (CA19-9). Known inflammatory indices (NLR and PLR) were also calculated. A total of 468 patients who were diagnosed with ESCC between December 2005 and December 2008 were retrospectively analyzed in this study. By utilizing univariate and multivariate Cox proportional hazard analyses, we found that PLT and MPV were significantly associated with overall survival (OS) and disease-free survival (DFS) of ESCC patients, with optimal cutoff values of 212 and 10.6, respectively. Moreover, the combination of the preoperative PLT and MPV (COP-MPV) was calculated as follows: patients with both PLT (≥212 × 10(9) L(-1)) and MPV (≥10.6 fL) elevation were assigned a score of 2, and patients with one or neither were assigned a score of 1 and 0. The COP-MPV was an independent prognostic factor for OS (hazard ratio (HR) 0.378, 95 % confidence interval (CI) 0.241 to 0.593, P < 0.001, 0/2) and DFS (HR 0.341, 95 % CI 0.218 to 0.534, P < 0.001, 0/2) in multivariate analyses. In subgroup analyses for early (stages I and II) and locally (stage III) advanced stage patients, COP-MPV was found significantly associated with OS and DFS in each group (P = 0.025 and P = 0.018 for OS and P = 0.029 and P = 0.002 for DFS). In conclusion, we considered that COP-MPV is a promising predictor for postoperative survival in ESCC patients.

Indexed as

Mean Platelet VolumeAdultAgedAged, 80 and overBlood PlateletsCarcinoma, Squamous CellEsophageal NeoplasmsFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm StagingPostoperative PeriodPrognosisRetrospective StudiesEsophageal squamous cell cancerMean platelet volumePlatelet countPrognosisScoring system

Identifiers

PMID26779631
PMCPMC4990601
OpenAlexW2260488123

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.