ArticleFrontiers in molecular biosciences2015
Characterization of the Olfactory Receptors Expressed in Human Spermatozoa.
Article in Frontiers in molecular biosciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- Evidence from computational infrared spectroscopy against vibrational detection of propionate by human olfactory receptor OR51E2.European biophysics journal : EBJ · 2026Article
- Molecular interplay between sperm and oocyte: a narrative review.Human reproduction update · 2026Review
- Seasonal Changes in the Seminal Plasma Proteome of the Crab-Eating Fox (Journal of proteome research · 2026Article
- Extra-nasal odorant receptors: molecular mechanisms and therapeutic implications.Frontiers in physiology · 2026Review
- Phthalate exposure to adult mice alters non-coding RNAs in cauda epididymosomes.Environmental pollution (Barking, Essex : 1987) · 2025Article
- Development and Optimization of an RNA-Isolating Protocol for Mammalian Spermatozoa.International journal of molecular sciences · 2025Article
- Exploring OR2H1-Mediated Sperm Chemotaxis: Development and Application of a Novel Microfluidic Device.Cells · 2025Article
- Roles of sensory receptors in non-sensory organs: the kidney and beyond.Nature reviews. Nephrology · 2025Review
- Influence of MHC on genetic diversity and testicular expression of linked olfactory receptor genes.BMC genomics · 2025Article
- Genomic study for pregnancy loss in Brahman cattle.Journal of animal science · 2025Article
- Proteostasis as a Sentry for Sperm Quality and Male Fertility.Advances in experimental medicine and biology · 2025Review
- Targeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity Treatment.Foods (Basel, Switzerland) · 2024Review
- Polymorphic pseudogenes in the human genome - a comprehensive assessment.Human genetics · 2024Article
- The Olfactory Receptor Olfr25 Mediates Sperm Dysfunction Induced by Low-Dose Bisphenol A through the CatSper-CaToxics · 2024Article
- Review
- Article
- Are the Olfactory Receptors Present at the Sperm Membrane Involved in Reproduction?International journal of molecular sciences · 2023Article
- Olfactory Receptors as an Emerging Chemical Sensing Scaffold.Biochemistry · 2023Review
- Odorant Receptor OR2C1 Is an Essential Modulator of Boar Sperm Capacitation by Binding with Heparin.International journal of molecular sciences · 2023Article
- Short-Chain Fatty Acids Modulate Sperm Migration through Olfactory Receptor 51E2 Activity.International journal of molecular sciences · 2022Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The detection of external cues is fundamental for human spermatozoa to locate the oocyte in the female reproductive tract. This task requires a specific chemoreceptor repertoire that is expressed on the surface of human spermatozoa, which is not fully identified to date. Olfactory receptors (ORs) are candidate molecules and have been attributed to be involved in sperm chemotaxis and chemokinesis, indicating an important role in mammalian spermatozoa. An increasing importance has been suggested for spermatozoal RNA, which led us to investigate the expression of all 387 OR genes. This study provides the first comprehensive analysis of OR transcripts in human spermatozoa of several individuals by RNA-Seq. We detected 91 different transcripts in the spermatozoa samples that could be aligned to annotated OR genes. Using stranded mRNA-Seq, we detected a class of these putative OR transcripts in an antisense orientation, indicating a different function, rather than coding for a functional OR protein. Nevertheless, we were able to detect OR proteins in various compartments of human spermatozoa, indicating distinct functions in human sperm. A panel of various OR ligands induced Ca(2+) signals in human spermatozoa, which could be inhibited by mibefradil. This study indicates that a variety of ORs are expressed at the mRNA and protein level in human spermatozoa.
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