ReviewFrontiers in pediatrics2015
The Corticospinal Tract: A Biomarker to Categorize Upper Limb Functional Potential in Unilateral Cerebral Palsy.
Review in Frontiers in pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- White matter lesions and DTI metrics related to various types of dysfunction in cerebral palsy: A meta-analysis and systematic review.PloS one · 2025Pooled it
- Three-dimensional assessment of finger individuation reveals finger- and joint-specific selective motor control deficits in children with cerebral palsy.Journal of neuroengineering and rehabilitation · 2026Trial
- Functional Neuroplasticity and Motor Skill Change Following Gross Motor Interventions for Children With Diplegic Cerebral Palsy.Neurorehabilitation and neural repair · 2023Trial
- Anatomical and Functional Characterization in Children With Unilateral Cerebral Palsy: An Atlas-Based Analysis.Neurorehabilitation and neural repair · 2020Trial
- PCR-Confirmed Convexity Subarachnoid Neurocysticercosis with Negative Serology: A Case Report.Pathogens (Basel, Switzerland) · 2026Article
- Association of corpus callosum and corticospinal tract microstructure with bimanual coordination in children with unilateral cerebral palsy.Experimental brain research · 2026Article
- Functional and structural neuroplasticity of somatosensory system in hemiplegic cerebral palsy.Brain communications · 2026Article
- Article
- Three-dimensional assessment of finger individuation reveals finger- and joint-specific selective motor control deficits in pediatric cerebral palsy.Research square · 2025Article
- Impact of Brain Lesion Characteristics on Motor Function and Cortical Reorganization in Hemiplegic Cerebral Palsy.Medicina (Kaunas, Lithuania) · 2025Article
- Neurobiological Insights Into Cerebral Palsy: A Review of the Mechanisms and Therapeutic Strategies.Brain and behavior · 2024Review
- Linking corticospinal tract activation and upper-limb motor control in adults with cerebral palsy.Developmental medicine and child neurology · 2024Article
- Transcutaneous spinal cord stimulation modulates quiet standing in healthy adults: stimulation site and cognitive style matter.Frontiers in neuroscience · 2024Article
- Neuromuscular adaptations of swallowing and speech in unilateral cerebral palsy: shared and distinctive traits.Journal of neurophysiology · 2023Article
- Article
- Neural Correlates of Impaired Grasp Function in Children with Unilateral Spastic Cerebral Palsy.Brain sciences · 2023Review
- Corticomuscular Coherence in Children with Unilateral Cerebral Palsy: A Feasibility and Preliminary Protocol Study.Journal of child neurology · 2023Article
- Asymmetry in sleep spindles and motor outcome in infants with unilateral brain injury.Developmental medicine and child neurology · 2022Article
- Development and validation of a novel model based on hand knob score and white matter injury on MRI to predict hand function in children with cerebral palsy.Annals of translational medicine · 2022Article
- Mapping white matter maturational processes and degrees on neonates by diffusion kurtosis imaging with multiparametric analysis.Human brain mapping · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children with unilateral cerebral palsy (CP) typically present with largely divergent upper limb sensorimotor deficits and individual differences in response to upper limb rehabilitation. This review summarizes how early brain damage can cause dramatic deviations from the normal anatomy of sensory and motor tracts, resulting in unique "wiring patterns" of the sensorimotor system in CP. Based on the existing literature, we suggest that corticospinal tract (CST) anatomy and integrity constrains sensorimotor function of the upper limb and potentially also the response to treatment. However, it is not possible to infer CST (re)organization from clinical presentation alone and conventional biomarkers, such as time of insult, location, and lesion extent seem to have limited clinical utility. Here, we propose a theoretical framework based on a detailed examination of the motor system using behavioral, neurophysiological, and magnetic resonance imaging measures, akin to those used to predict potential for upper limb recovery of adults after stroke. This theoretical framework might prove useful because it provides testable hypotheses for future research with the goal to develop and validate a clinical assessment flowchart to categorize children with unilateral CP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.