ArticleFrontiers in cellular and infection microbiology2015
Smooth to Rough Dissociation in Brucella: The Missing Link to Virulence.
Article in Frontiers in cellular and infection microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Blood Culture-Negative Endocarditis: A Scientific Statement From the American Heart Association:Journal of the American Heart Association · 2025Guideline
- Biological characteristics, human cell interaction mechanisms, and differential clinical outcomes of infection by Brucella melitensis, Brucella abortus, Brucella suis, and Brucella canis.Archives of microbiology · 2026Review
- Genomic analysis of Brucella Ovis in Italy reveals high genetic diversity and a novel lineage.BMC veterinary research · 2026Article
- First isolation and identification ofFrontiers in microbiology · 2025Article
- Development of a colloidal gold immunochromatographic test strip for detecting the smooth Brucella.Scientific reports · 2024Article
- Molecular typing methods to characterizeVeterinary world · 2024Review
- Russian collection ofFrontiers in veterinary science · 2023Article
- Importance of brucellosis control programs of livestock on the improvement of one health.The veterinary quarterly · 2021Review
- Risk factors for leptospirosis and brucellosis in people living with human immunodeficiency virus who attended a referral hospital in southeastern Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2021Article
- Presumptive Identification of SmoothFrontiers in veterinary science · 2021Article
- When the Going Gets Rough: The Significance ofFrontiers in microbiology · 2021Review
- Genomic Analysis of Natural RoughInternational journal of molecular sciences · 2020Article
- Whole-genome sequencing of roughEmerging microbes & infections · 2020Article
- Development of a Genus-SpecificVeterinary sciences · 2020Article
- Periplasmic protein EipA determines envelope stress resistance and virulence in Brucella abortus.Molecular microbiology · 2019Article
- Bifidobacterium adolescentis is intrinsically resistant to antitubercular drugs.Scientific reports · 2018Article
- Review
- Article
- AFrontiers in cellular and infection microbiology · 2016Article
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1 author.
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Abstract
Dissociation encompasses changes in a series of phenotypes: colony and cell morphology, inmunological and biochemical reactions and virulence. The concept is generally associated to the in vitro transition between smooth (S) and rough (R) colonies, a phenotypic observation in Gram-negative bacteria commonly made since the beginning of microbiology as a science. It is also well known that the loss of the O-polysaccharide, the most external lipopolysaccharide (LPS) moiety, triggers the change in the colony phenotype. Although dissociation is related to one of the most basic features used to distinguish between species, i.e., colony morphology, and, in the case of pathogens, predict their virulence behavior, it has been considered a laboratory artifact and thus did not gain further attention. However, recent insights into genetics and pathogenesis of members of Brucella, causative agents of brucellosis, have brought a new outlook on this experimental fact, suggesting that it plays a role beyond the laboratory observations. In this perspective article, the current knowledge on Brucella LPS genetics and its connection with dissociation in the frame of evolution is discussed. Latest reports support the notion that, by means of a better understanding of genetic pathways linked to R phenotype and the biological impact of this intriguing "old" phenomenon, unexpected applications can be achieved.
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