ArticleFrontiers in cellular and infection microbiology2015
Total Antioxidant Capacity and Total Oxidant Status in Saliva of Periodontitis Patients in Relation to Bacterial Load.
Article in Frontiers in cellular and infection microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Meta-Analysis of Assessment of Total Oxidative Stress and Total Antioxidant Capacity in Patients with Periodontitis.Disease markers · 2023Pooled it
- Evaluation of melatonin gel as local drug delivery system for the treatment of periodontitis: a split-mouth randomized controlled trial.BMC oral health · 2025Trial
- Evaluation of saliva and serum heme oxygenase, arylesterase and nuclear factor erythroid 2-related factor 2 levels in patients with stage III periodontitis: a cross sectional study.Clinical oral investigations · 2026Article
- Salivary mitofusin levels in periodontal disease: a cross-sectional case-control study.BMC oral health · 2025Article
- miR-9-5p alleviates the development of abdominal aortic aneurysm by regulating the differentiation of CD4Turkish journal of biology = Turk biyoloji dergisi · 2025Article
- Effect of bioactive peptides on heat stress-induced testiculopathies in mature rats: immunohistopathological evidence.Veterinary research forum : an international quarterly journal · 2025Article
- Minimizing Oxidative Stress in Oral Surgery: A Comparative Study of Laser-Assisted and Conventional Third Molar Extractions.Dentistry journal · 2024Article
- Article
- The Influence of Circadian Rhythm on the Antioxidant Capacity of Saliva in Periodontal Diseases.Cureus · 2024Article
- The Emerging Role of Salivary Oxidative Stress Biomarkers as Prognostic Markers of Periodontitis: New Insights for a Personalized Approach in Dentistry.Journal of personalized medicine · 2023Review
- Thiogenistein-Antioxidant Chemistry, Antitumor Activity, and Structure Elucidation of New Oxidation Products.International journal of molecular sciences · 2022Article
- The correlation between serum inflammatory, antioxidant, glucose handling biomarkers, and Dietary Antioxidant Index (DAI) and the role of DAI in obesity/overweight causation: population-based case-control study.International journal of obesity (2005) · 2021Article
- Salivary Oxidative Stress Markers' Relation to Oral Diseases in Children and Adolescents.Antioxidants (Basel, Switzerland) · 2021Article
- Comparison of Anti-Oxidative Effect of Human Adipose- and Amniotic Membrane-Derived Mesenchymal Stem Cell Conditioned Medium on Mouse Preimplantation Embryo Development.Antioxidants (Basel, Switzerland) · 2021Article
- Effect of Locally Delivered Melatonin as an Adjunct to Nonsurgical Therapy on GCF Antioxidant Capacity and MMP-9 in Stage II Periodontitis Patients: A Randomized Controlled Clinical Trial.International journal of dentistry · 2021Article
- In medical research, what appears to be intuitive and sensible might be erroneous: percent change from baseline.Croatian medical journal · 2020Article
- Total Oxidant and Antioxidant Capacity of Gingival Crevicular Fluid and Saliva in Patients with Periodontitis: Review and Clinical Study.Antioxidants (Basel, Switzerland) · 2020Article
- Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan.Scientific reports · 2020Article
- Effect of nonsurgical periodontal therapy on the level of salivary antioxidants in patients with generalized moderate-to-severe chronic periodontitis.Journal of advanced periodontology & implant dentistry · 2019Article
- The effects of cigarette smoking and exercise on total salivary antioxidant activity.The Saudi dental journal · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The detection of salivary biomarkers has a potential application in early diagnosis and monitoring of periodontal inflammation. However, searching sensitive salivary biomarkers for periodontitis is still ongoing. Oxidative stress is supposed to play an important role in periodontitis progression and tissue destruction. In this cross-sectional study, we investigated total antioxidant capacity (TAC) and total oxidant status (TOS) in saliva of periodontitis patients compared to healthy controls and their relationship with periodontopathic bacteria and periodontal disease severity. Unstimulated saliva was collected from 45 patients with generalized severe periodontitis and 37 healthy individuals and the TAC/TOS were measured. In addition, salivary levels of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Fusobacterium nucleatum in saliva were measured. Salivary TAC was lower in periodontitis patients compared to healthy controls. Moreover, a significant negative correlation of salivary TAC with clinical attachment loss was observed in periodontitis patients. No significant difference in the salivary TOS was observed between periodontitis patients and healthy controls. Bacterial load was enhanced in periodontitis patients and exhibited correlation with periodontal disease severity but not with salivary TAC/TOS. Our data suggest that changes in antioxidant capacity in periodontitis patients are not associated with increased bacterial load and are probably due to a dysregulated immune response.
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