Evidence map›Paper›PMID 26779441›Full record

ArticleFrontiers in oncology2015

Human Papilloma Virus Identification in Breast Cancer Patients with Previous Cervical Neoplasia.

James S Lawson, Wendy K Glenn, Daria Salyakina, Rosemary Clay, Warick Delprado, Bharathi Cheerala, Dinh D Tran, Christopher C Ngan, Shingo Miyauchi, Martha Karim and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Review
  8. The viral origins of breast cancer.Infectious agents and cancer · 2024
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. HPV-Associated Breast Cancer: Myth or Fact?Pathogens (Basel, Switzerland) · 2022
    Review
  16. Article
  17. Review
  18. Interrelated Oncogenic Viruses and Breast Cancer.Frontiers in molecular biosciences · 2022
    Review
  19. Review
  20. Catching viral breast cancer.Infectious agents and cancer · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

James S LawsonSchool of Biotechnology and Biomolecular Science, University of New South Wales , Sydney, NSW , Australia.
Wendy K GlennSchool of Biotechnology and Biomolecular Science, University of New South Wales , Sydney, NSW , Australia.
Daria SalyakinaCenter for Computational Science, University of Miami , Miami, FL , USA.
Rosemary ClayDouglass Hanly Moir - Pathology , Macquarie Park, NSW , Australia.
Warick DelpradoDouglass Hanly Moir - Pathology , Macquarie Park, NSW , Australia.
Bharathi CheeralaDouglass Hanly Moir - Pathology , Macquarie Park, NSW , Australia.
Dinh D TranSchool of Biotechnology and Biomolecular Science, University of New South Wales , Sydney, NSW , Australia.
Christopher C NganSchool of Biotechnology and Biomolecular Science, University of New South Wales , Sydney, NSW , Australia.
Shingo MiyauchiSchool of Biotechnology and Biomolecular Science, University of New South Wales , Sydney, NSW , Australia.
Martha KarimSchool of Biotechnology and Biomolecular Science, University of New South Wales , Sydney, NSW , Australia.
Annika AntonssonQIMR Berghofer Medical Research Institute , Brisbane, QLD , Australia.
Noel J WhitakerSchool of Biotechnology and Biomolecular Science, University of New South Wales , Sydney, NSW , Australia.

Funding

Identification of Novel Viruses Associated with Malignant DiseasesR03CA171052 · NCI · UNIVERSITY OF MIAMI CORAL GABLES · PI SALYAKINA, DARIA · 2013 to 2014
$139k
NCI NIH HHS R03 CA171052
6 · The paper itself

Abstract

purposeWomen with human papilloma virus (HPV)-associated cervical neoplasia have a higher risk of developing breast cancer than the general female population. The purpose of this study was to (i) identify high-risk HPVs in cervical neoplasia and subsequent HPV positive breast cancers which developed in the same patients and (ii) determine if these HPVs were biologically active.

methodsA range of polymerase chain reaction and immunohistochemical techniques were used to conduct a retrospective cohort study of cervical precancers and subsequent breast cancers in the same patients.

resultsThe same high-risk HPV types were identified in both the cervical and breast specimens in 13 (46%) of 28 patients. HPV type 18 was the most prevalent. HPVs appeared to be biologically active as demonstrated by the expression of HPV E7 proteins and the presence of HPV-associated koilocytes. The average age of these patients diagnosed with breast cancer following prior cervical precancer was 51 years, as compared to 60 years for all women with breast cancer (p for difference = 0.001).

conclusionThese findings indicate that high-risk HPVs can be associated with cervical neoplasia and subsequent young age breast cancer. However, these associations are unusual and are a very small proportion of breast cancers. These outcomes confirm and extend the observations of two similar previous studies and offer one explanation for the increased prevalence of serious invasive breast cancer among young women.

Indexed as

breast cancercervical neoplasiahuman papilloma virusesyoung age

Identifiers

PMID26779441
PMCPMC4705232

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.