Evidence map›Paper›PMID 26779417›Full record

ArticleCurrent stem cell reports2015

Regulatory T Cell Immunotherapy in Immune-Mediated Diseases.

Antonio Pierini, Dominik Schneidawind, Hidekazu Nishikii, Robert S Negrin

Open access · bronzeAbstract read
In one paragraph

Article in Current stem cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Recent advances in CD8Oncology letters · 2018
    Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Antonio PieriniBlood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA; Hematology and Clinical Immunology, Department of Medicine, University of Perugia, Perugia, Italy.
Dominik SchneidawindBlood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine II, Eberhard Karls University, Tübingen, Germany.
Hidekazu NishikiiBlood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA; Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Robert S NegrinBlood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA.
Stanford University · US

Funding

TUMOR SPECIFIC CYTOTOXIC T-LYMPHOCYTES IN BONE MARROW TRANSPLANTATIONP01CA049605 · NCI · STANFORD UNIVERSITY · PI David B. Miklos · 1989 to 2026
$73.3M
TLI/ATG CONDTIONING: KIDNEY/BLOOD STEM CELL TRANSPLANTSP01HL075462 · NHLBI · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G. · 2004 to 2020
$27.9M
Regulatory T cells in allogeneic transplantationR01HL114591 · NHLBI · STANFORD UNIVERSITY · PI NEGRIN, ROBERT S · 2012 to 2016
$2.6M
NCI NIH HHS P01 CA049605NHLBI NIH HHS P01 HL075462NHLBI NIH HHS R01 HL114591
6 · The paper itself

Abstract

Broad clinical interest rapidly followed the recent discovery of different subpopulations of T cells that have immune regulatory properties and a number of studies have been conducted aiming to dissect the translational potential of these promising cells. In this review we will focus on forkhead box P3 (FoxP3) positive regulatory T cells, T regulatory type 1 cells and invariant natural killer T cells (iNKT). We will analyze their ability to correct immune dysregulation in animal models of immune mediated diseases and we will examine the first clinical approaches where these cells have been directly or indirectly employed. We will discuss successes, challenges and limitations that rose in the road to the clinical use of regulatory T cells.

Indexed as

FoxP3+ T regulatory cellsGraft versus Host DiseaseHematopoietic Stem Cell TransplantationInvariant Natural Killer T cellsTolerance InductionT regulatory type 1 cells

Identifiers

PMID26779417
PMCPMC4712720
OpenAlexW2232901107

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.