ArticleCancer biology & medicine2015
How to select elderly colorectal cancer patients for surgery: a pilot study in an Italian academic medical center.
Article in Cancer biology & medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Frailty worsens long-term survival in patients with colorectal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Frailty and long-term survival of patients with colorectal cancer: a meta-analysis.Aging clinical and experimental research · 2022Pooled it
- Physical function predicts mortality in patients with cancer: a systematic review and meta-analysis of observational studies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Pooled it
- Construction and validation of frailty risk prediction model in elderly patients with colorectal cancer.BMC geriatrics · 2025Article
- Identification of risk factors for postoperative complications after right colectomy and low anterior resection in patients ≥85 years old with colorectal cancer using the National Clinical Database.Annals of gastroenterological surgery · 2025Article
- Association between 5-item modified frailty index and clinical outcomes in elderly rectal cancer patients after radical surgery.Scientific reports · 2025Article
- Relationship between multiple morbidities and performance on the Timed Up and Go test in elderly patients: a cross-sectional study.BMJ open · 2025Article
- Prevalence and risk factors of frailty in patients with gynecological malignancies after surgery and chemotherapy: a cross-sectional study.Frontiers in oncology · 2025Article
- Timed up and go test and long-term survival in older adults after oncologic surgery.BMC geriatrics · 2022Article
- Article
- The Pre-Operative GRADE Score Is Associated with 5-Year Survival among Older Patients with Cancer Undergoing Surgery.Cancers · 2021Article
- Influence of Frailty on Outcome in Older Patients Undergoing Non-Cardiac Surgery - A Systematic Review and Meta-Analysis.Aging and disease · 2020Review
- Surgical approach and geriatric evaluation for elderly patients with colorectal cancer.Updates in surgery · 2019Review
- VES-13 and WHOQOL-bref cutoff points to detect quality of life in older adults in primary health care.Revista de saude publica · 2019Article
- Association Between Adjuvant Chemotherapy and Overall Survival in Patients With Rectal Cancer and Pathological Complete Response After Neoadjuvant Chemotherapy and Resection.JAMA oncology · 2018Article
- Integration of Geriatric Assessment in the Care of Patients with Gastrointestinal Malignancies.Visceral medicine · 2017Review
- Risk Factors for Adverse Outcome for Elderly Patients undergoing Curative Oncological Resection for Gastrointestinal Malignancies.Visceral medicine · 2017Review
- Surgery of the elderly in emergency room mode. Is there a place for laparoscopy?Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2017Article
- How should older adults with cancer be evaluated for frailty?Journal of geriatric oncology · 2017Review
- Enhanced Recovery After Colorectal Surgery (ERAS) in Elderly Patients Is Feasible and Achieves Similar Results as in Younger Patients.Gerontology & geriatric medicineArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCancer is one of the most common diagnoses in elderly patients. Of all types of abdominal cancer, colorectal cancer (CRC) is undoubtedly the most frequent. Median age at diagnosis is approximately 70 years old worldwide. Due to the multiple comorbidities affecting elderly people, frailty evaluation is very important in order to avoid over- or under-treatment. This pilot study was designed to investigate the variables capable of predicting the long-term risk of mortality and living situation after surgery for CRC.
methodsPatients with 70 years old and older undergoing elective surgery for CRC were prospectively enrolled in the study. The patients were preoperatively screened using 11 internationally-validated-frailty-assessment tests. The endpoints of the study were long-term mortality and living situation. The data were analyzed using univariate Cox proportional-hazard regression analysis to verify the predictive value of score indices in order to identify possible risk factors.
resultsForty-six patients were studied. The median follow-up time after surgery was 4.6 years (range, 2.9-5.7 years) and no patients were lost to follow-up. The overall mortality rate was 39%. Four of the patients who survived (4/28, 14%) lost their functional autonomy. The preoperative impaired Timed Up and Go (TUG), Eastern Cooperative Group Performance Status (ECOG PS), Instrumental Activities of Daily Living (IADLs), Vulnerable Elders Survey (VES-13) scoring systems were significantly associated with increased long term mortality risk.
conclusionSimplified frailty-assessing tools should be routinely used in elderly cancer patients before treatment in order to stratify patient risk. The TUG, ECOG-PS, IADLs and VES-13 scoring systems are potentially able to predict long-term mortality and disability. Additional studies will be needed to confirm the preliminary data in order to improve management strategies for oncogeriatric surgical patients.
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