Evidence map›Paper›PMID 26779261›Full record

ReviewInternational journal of endocrinology2015

The Role of the Multiple Hormonal Dysregulation in the Onset of "Anemia of Aging": Focus on Testosterone, IGF-1, and Thyroid Hormones.

Marcello Maggio, Francesca De Vita, Alberto Fisichella, Fulvio Lauretani, Andrea Ticinesi, Graziano Ceresini, Anne Cappola, Luigi Ferrucci, Gian Paolo Ceda

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Preoperative splenic area as a prognostic biomarker of early-stage non-small cell lung cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. [Anemia in the aged].Zeitschrift fur Gerontologie und Geriatrie · 2018
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Marcello MaggioDepartment of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, 43126 Parma, Italy; Geriatric Rehabilitation Department, University Hospital of Parma, 43126 Parma, Italy.
Francesca De VitaDepartment of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, 43126 Parma, Italy.
Alberto FisichellaDepartment of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, 43126 Parma, Italy.
Fulvio LauretaniGeriatric Rehabilitation Department, University Hospital of Parma, 43126 Parma, Italy.
Andrea TicinesiDepartment of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, 43126 Parma, Italy.
Graziano CeresiniDepartment of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, 43126 Parma, Italy; Geriatric Rehabilitation Department, University Hospital of Parma, 43126 Parma, Italy.
Anne CappolaDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Luigi FerrucciNational Institute on Aging, National Institutes of Health (NIH), Baltimore, MD 21201, USA.
Gian Paolo CedaDepartment of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, 43126 Parma, Italy; Geriatric Rehabilitation Department, University Hospital of Parma, 43126 Parma, Italy.
University of Parma · ITNational Institutes of Health · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anemia is a multifactorial condition whose prevalence increases in both sexes after the fifth decade of life. It is a highly represented phenomenon in older adults and in one-third of cases is "unexplained." Ageing process is also characterized by a "multiple hormonal dysregulation" with disruption in gonadal, adrenal, and somatotropic axes. Experimental studies suggest that anabolic hormones such as testosterone, IGF-1, and thyroid hormones are able to increase erythroid mass, erythropoietin synthesis, and iron bioavailability, underlining a potential role of multiple hormonal changes in the anemia of aging. Epidemiological data more consistently support an association between lower testosterone and anemia in adult-older individuals. Low IGF-1 has been especially associated with anemia in the pediatric population and in a wide range of disorders. There is also evidence of an association between thyroid hormones and abnormalities in hematological parameters under overt thyroid and euthyroid conditions, with limited data on subclinical statuses. Although RCTs have shown beneficial effects, stronger for testosterone and the GH-IGF-1 axis and less evident for thyroid hormones, in improving different hematological parameters, there is no clear evidence for the usefulness of hormonal treatment in improving anemia in older subjects. Thus, more clinical and research efforts are needed to investigate the hormonal contribution to anemia in the older individuals.

Identifiers

PMID26779261
PMCPMC4686706
OpenAlexW2193172428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.