ArticleFrontiers in microbiology2015
The LuxS Based Quorum Sensing Governs Lactose Induced Biofilm Formation by Bacillus subtilis.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 99 citations in OpenAlex.
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- Effects of Autoinducer-2 on rumen bacterial community succession during in vitro fermentation with oat andFrontiers in microbiology · 2026Article
- Modulating gut microbial biofilms for intestinal barrier repair: opportunities in nutritional intervention.Frontiers in nutrition · 2026Review
- Probiotic potential and safety properties ofFrontiers in microbiology · 2025Article
- Bacillus xiamenensis Inhibits the Growth of Moraxella osloensis by Producing Indole-3-Carboxaldehyde.MicrobiologyOpen · 2024Article
- Synthesis, Characterization, and Docking Study of Novel Thioureidophosphonate-Incorporated Silver Nanocomposites as Potent Antibacterial Agents.Pharmaceutics · 2023Article
- Regulation of biofilm formation inFrontiers in bioengineering and biotechnology · 2023Article
- Pyrones Identified as LuxR Signal Molecules inACS omega · 2021Article
- Review
- Two Lysine Sites That Can Be Malonylated Are Important for LuxS Regulatory Roles inMicroorganisms · 2021Article
- Microbial Biofilms in the Food Industry-A Comprehensive Review.International journal of environmental research and public health · 2021Review
- Genome sequence analysis of the beneficial Bacillus subtilis PTA-271 isolated from a Vitis vinifera (cv. Chardonnay) rhizospheric soil: assets for sustainable biocontrol.Environmental microbiome · 2021Article
- Exploring interfacial dynamics in homodimericRSC advances · 2021Article
- Combination of beneficial bacteria improves blueberry production and soil quality.Food science & nutrition · 2020Article
- Mitigating Milk-Associated Bacteria through Inducing Zinc Ions Antibiofilm Activity.Foods (Basel, Switzerland) · 2020Article
- Bifidobacterial biofilm formation is a multifactorial adaptive phenomenon in response to bile exposure.Scientific reports · 2020Article
- Evaluation of two fixation techniques for direct observation of biofilm formation ofVeterinary world · 2020Article
- Bacterial Community Members IncreasePhytobiomes journal · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacillus species present a major concern in the dairy industry as they can form biofilms in pipelines and on surfaces of equipment and machinery used in the entire line of production. These biofilms represent a continuous hygienic problem and can lead to serious economic losses due to food spoilage and equipment impairment. Biofilm formation by Bacillus subtilis is apparently dependent on LuxS quorum sensing (QS) by Autoinducer-2 (AI-2). However, the link between sensing environmental cues and AI-2 induced biofilm formation remains largely unknown. The aim of this study is to investigate the role of lactose, the primary sugar in milk, on biofilm formation by B. subtilis and its possible link to QS processes. Our phenotypic analysis shows that lactose induces formation of biofilm bundles as well as formation of colony type biofilm. Furthermore, using reporter strain assays, we observed an increase in AI-2 production by B. subtilis in response to lactose in a dose dependent manner. Moreover, we found that expression of eps and tapA operons, responsible for extracellular matrix synthesis in B. subtilis, were notably up-regulated in response to lactose. Importantly, we also observed that LuxS is essential for B. subtilis biofilm formation in the presence of lactose. Overall, our results suggest that lactose may induce biofilm formation by B. subtilis through the LuxS pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.