ArticleFrontiers in microbiology2015
Isolation and Genetic Analysis of Multidrug Resistant Bacteria from Diabetic Foot Ulcers.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Prevalence of multidrug-resistant bacterial infections in diabetic foot ulcers: A meta-analysis.International wound journal · 2024Pooled it
- Changing paradigm of antibiotic resistance amongst Escherichia coli isolates in Indian pediatric population.PloS one · 2019Trial
- A Systematic Review and Meta-Analysis Comparing the Diagnostic Accuracy of Swab Cultures and Tissue Biopsy for Diagnosing Diabetic Foot Infections.International journal of endocrinology · 2026Review
- Integrating clinical data into evidence-based practice: institutional guideline development for diabetic foot infections.Frontiers in endocrinology · 2026Article
- Antimicrobial resistance profiles and detection of mecA, blaCTX-M-1, and blaSHV genes in bacteria among diabetic foot ulcer patients from selected referral hospitals in Uganda.BMC infectious diseases · 2025Article
- Antimicrobial Potential of Bacteriophages JG005 and JG024 AgainstVeterinary sciences · 2025Article
- Deciphering Diabetic Foot Wounds: A Comprehensive Review on Classification, Multidrug Resistance, Microbial Insights, Management & Treatment Strategies, and Advanced Diagnostic Tools.Current diabetes reviews · 2025Review
- An Update on Diabetic Foot Ulcer and Its Management Modalities.Indian journal of microbiology · 2024Review
- Modulations of the skin microbiome in skin disorders: A narrative review from a wound care perspective.International wound journal · 2024Review
- Clinical perspectives on sampling and processing approaches for the management of infection in diabetic foot ulceration: A qualitative study.International wound journal · 2024Article
- Antibacterial effects of single phage and phage cocktail against multidrug-resistant Klebsiella pneumoniae isolated from diabetic foot ulcer.Virus genes · 2023Article
- An Overview of Diabetic Foot Ulcers and Associated Problems with Special Emphasis on Treatments with Antimicrobials.Life (Basel, Switzerland) · 2022Review
- Article
- Isolation and Characterization of StrainMicroorganisms · 2021Article
- Characterization of a New Mixture of Mono-Rhamnolipids Produced byMarine drugs · 2020Article
- Lytic Bacteriophage Screening Strategies for Multidrug-Resistant Bloodstream Infections in a Burn Intensive Care Unit.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Evaluation of Drug Susceptibility of Microorganisms in Odontogenic Inflammations and Dental Surgery Procedures Performed on an Outpatient Basis.BioMed research international · 2019Article
- Integron Digestive Carriage in Human and Cattle: A "One Health" Cultivation-Independent Approach.Frontiers in microbiology · 2017Article
- Isolation and in vitro evaluation of bacteriophages against MDR-bacterial isolates from septic wound infections.PloS one · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe diabetic foot ulcers (DFUs) patients visiting Sir Sunderlal Hospital, Banaras Hindu University, Varanasi, were selected for this study. Bacteria were isolated from swab and deep tissue of 42 patients, for examining their prevalence and antibiotic sensitivity. DFUs of majority of the patients were found infected with Enterococcus spp. (47.61%), Escherichia coli (35.71%), Staphylococcus spp. (33.33%), Alcaligenes spp. (30.95%), Pseudomonas spp. (30.95%), and Stenotrophomonas spp. (30.95%). Antibiotic susceptibility assay of 142 bacteria with 16 antibiotics belonging to eight classes showed the presence of 38 (26.76%) isolates with multidrug resistance (MDR) phenotypes. MDR character appeared to be governed by integrons as class 1 integrons were detected in 26 (68.42%) isolates. Altogether six different arrays of genes (aadA1, aadB, aadAV, dhfrV, dhfrXII, and dhfrXVII) were found within class 1 integron. Gene cassette dhfrAXVII-aadAV (1.6 kb) was present in 12 (3 Gram positive and 9 Gram negative) isolates and was conserved across all the isolates as evident from RFLP analysis. In addition to the presence of class 1 integron, six β-lactamase resistance encoding genes namely bla TEM, bla SHV, bla OXA, bla CTX-M-gp1, bla CTX-M-gp2, and bla CTX-M-gp9 and two methicillin resistance genes namely mecA and femA and vancomycin resistance encoding genes (vanA and vanB) were identified in different isolates. Majority of the MDR isolates were positive for bla TEM (89.47%), bla OXA (52.63%), and bla CTX-M-gp1 (34.21%). To our knowledge, this is the first report of molecular characterization of antibiotic resistance in bacteria isolated from DFUs from North India. In conclusion, findings of this study suggest that class-1 integrons and β-lactamase genes contributed to the MDR in above bacteria.
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