ArticleFrontiers in psychology2015
Translating Genetic Research into Preventive Intervention: The Baseline Target Moderated Mediator Design.
Article in Frontiers in psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Research Review: Mechanisms of change and between-family differences in parenting interventions for children with ADHD - an individual participant data meta-analysis.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Familias Unidas Prevents Youth Internalizing Symptoms: a Baseline Target Moderated Mediation (BTMM) Study.Prevention science : the official journal of the Society for Prevention Research · 2023Trial
- Emotion Regulation Difficulties in Military Fathers Magnify Their Benefit from a Parenting Program.Prevention science : the official journal of the Society for Prevention Research · 2023Trial
- Exploring the Mechanisms in Cognitive Behavioural Therapy for Anxious Children: Does Change in Emotion Regulation Explain Treatment Effect?Prevention science : the official journal of the Society for Prevention Research · 2023Trial
- Mediational Effects on Motivation to Quit Smoking After Exposure to a Cigarette Pictorial Warning Label Among Young Adults.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2022Trial
- Implementation intentions to express gratitude increase daily time co-present with an intimate partner, and moderate effects of variation in CD38.Scientific reports · 2022Trial
- Longitudinal effects of cigarette pictorial warning labels among young adults.Journal of behavioral medicine · 2022Trial
- What does a population-level mediation reveal about individual people?Behavior research methods · 2024Article
- Gene × environment effects and mediation involving adverse childhood events, mood and anxiety disorders, and substance dependence.Nature human behaviour · 2024Article
- Adverse Childhood Events, Mood and Anxiety Disorders, and Substance Dependence: Gene x Environment Effects and Moderated Mediation.Research square · 2023Article
- Adverse Childhood Events, Mood and Anxiety Disorders, and Substance Dependence: Gene X Environment Effects and Moderated Mediation.medRxiv : the preprint server for health sciences · 2023Article
- Exploring Parenting Profiles to Understand Who Benefits from the Incredible Years Parenting Program.Prevention science : the official journal of the Society for Prevention Research · 2023Article
- When Is It Time to Revise or Adapt Our Prevention Programs? Introduction to Special Issue on Using Baseline Target Moderation to Assess Variation in Prevention Impact.Prevention science : the official journal of the Society for Prevention Research · 2023Article
- Family Functioning in Hispanic Parents of Adolescents: Who Benefits Most from a Family-Based HIV and Substance Use Preventive Intervention?Prevention science : the official journal of the Society for Prevention Research · 2023Article
- Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated.Development and psychopathology · 2021Article
- Assessing Stakeholder Perceptions of the Utility of Genetic Information for the Clinical Care of Mental Health Disorders: We Have a Will but Need to See the Way.Administration and policy in mental health · 2021Article
- Developing community-based health education strategies with family history: Assessing the association between community resident family history and interest in health education.Social science & medicine (1982) · 2021Article
- Preventive Effect Heterogeneity: Causal Inference in Personalized Prevention.Prevention science : the official journal of the Society for Prevention Research · 2019Article
- Do Less Mindful Mothers Show Better Parenting via Improvements in Trait Mindfulness Following a Military Parent Training Program?Frontiers in psychology · 2019Article
- Decision-making style and response to parental involvement in brief interventions for adolescent substance use.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In this paper we present and discuss a novel research approach, the baseline target moderated mediation (BTMM) design, that holds substantial promise for advancing our understanding of how genetic research can inform prevention research. We first discuss how genetically informed research on developmental psychopathology can be used to identify potential intervention targets. We then describe the BTMM design, which employs moderated mediation within a longitudinal study to test whether baseline levels of intervention targets moderate the impact of the intervention on change in that target, and whether change in those targets mediates causal impact of preventive or treatment interventions on distal health outcomes. We next discuss how genetically informed BTMM designs can be applied to both microtrials and full-scale prevention trials. We use simulated data to illustrate a BTMM, and end with a discussion of some of the advantages and limitations of this approach.
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