ReviewFrontiers in psychology2015
Neuromodulation of Aerobic Exercise-A Review.
Review in Frontiers in psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05561192 (Effects of Insertion of Diaphragmatic Breathing Exercises, Cardiorespiratory and Strength Exercises, and Cooperative Sports Activities During Physical Education Classes on Anxiety and Depression Symptoms in Adolescents), which is not on this map. Cited by 155 papers, 16 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Insertion of Diaphragmatic Breathing Exercises, Cardiorespiratory and Strength Exercises, and Cooperative Sports Activities During Physical Education Classes on Anxiety and Depression Symptoms in Adolescents
Who cites it
155 citing papers in PubMed, 16 syntheses or guidelines pooled it, 339 citations in OpenAlex.
- Dose-response relationship between exercise interventions and motor skills in children with autism spectrum disorder: a systematic review and multilevel meta-analysis.European journal of pediatrics · 2026Pooled it
- Additional treatment strategies for hypothyroidism: a network meta-analysis.Endocrine connections · 2026Pooled it
- Effects of different exercise types on body image in females: a systematic review and network meta-analysis.Frontiers in psychology · 2026Pooled it
- The influence of outdoor physical activity on the physical and mental health of college students: a systematic review.Frontiers in psychology · 2026Pooled it
- The effectiveness of dance interventions on sleep quality: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- The effect of exercise interventions on mental health in children and adolescents with attention-deficit/hyperactivity disorder: a meta-analysis.Frontiers in psychology · 2026Pooled it
- Effects of different types of physical activities on self-esteem in typically developing children and adolescents: a systematic review and network meta-analysis.Frontiers in public health · 2026Pooled it
- Effects of aerobic exercise on cognitive function in older adults with mild cognitive impairment: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Effects of physical exercise interventions on multidimensional health outcomes in patients with substance use disorders: a network meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Optimal exercise modality and dose for alleviating depressive symptoms in postmenopausal women: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in psychology · 2025Pooled it
- Optimal aerobic exercise dose for pain relief in fibromyalgia syndrome: a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- A network meta-analysis of mind-body exercise interventions for internet addiction symptoms in young adults.Frontiers in public health · 2025Pooled it
- Effects of aerobic exercise interventions on cognitive function, sleep quality, and quality of life in older adults with mild cognitive impairment: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Effect of aerobic exercise on the improvement of executive function in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis.Frontiers in psychology · 2024Pooled it
- Physical activity interventions for cardiopulmonary fitness in obese children and adolescents: a systematic review and meta-analysis.BMC pediatrics · 2023Pooled it
- Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes.Journal of the International Society of Sports Nutrition · 2016Pooled it
- The effects of physical activity on mental health in adolescents with attention-deficit hyperactivity disorder: a randomized controlled trial.The international journal of behavioral nutrition and physical activity · 2025Trial
- Effectiveness of Mobile-Based Progressive and Fixed Physical Activity on Depression, Stress, Anxiety, and Quality of Life Outcomes Among Adults in South Korea: Randomized Controlled Trial.JMIR mHealth and uHealth · 2024Trial
- Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2023Trial
- The Effectiveness of a Mobile Phone-Based Physical Activity Program for Treating Depression, Stress, Psychological Well-Being, and Quality of Life Among Adults: Quantitative Study.JMIR mHealth and uHealth · 2023Trial
95 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Running, and aerobic exercise in general, is a physical activity that increasingly many people engage in but that also has become popular as a topic for scientific research. Here we review the available studies investigating whether and to which degree aerobic exercise modulates hormones, amino acids, and neurotransmitters levels. In general, it seems that factors such as genes, gender, training status, and hormonal status need to be taken into account to gain a better understanding of the neuromodular underpinnings of aerobic exercise. More research using longitudinal studies and considering individual differences is necessary to determine actual benefits. We suggest that, in order to succeed, aerobic exercise programs should include optimal periodization, prevent overtraining and be tailored to interindividual differences, including neuro-developmental and genetically-based factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.