ArticleFrontiers in physiology2015
Simulation of Cl(-) Secretion in Epithelial Tissues: New Methodology Estimating Activity of Electro-Neutral Cl(-) Transporter.
Article in Frontiers in physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Trichomonas vaginalis infection impairs anion secretion in vaginal epithelium.PLoS neglected tropical diseases · 2021Article
- Interactive Actions of Aldosterone and Insulin on Epithelial NaInternational journal of molecular sciences · 2020Article
- Daidzein-Stimulated Increase in the Ciliary Beating Amplitude via an [ClInternational journal of molecular sciences · 2018Article
- The Proposal of Molecular Mechanisms of Weak Organic Acids Intake-Induced Improvement of Insulin Resistance in Diabetes Mellitus via Elevation of Interstitial Fluid pH.International journal of molecular sciences · 2018Review
- The Mechanistic Links between Insulin and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) ClInternational journal of molecular sciences · 2017Review
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Authors and funding
4 authors.
Funding
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Abstract
Transcellular Cl(-) secretion is, in general, mediated by two steps; (1) the entry step of Cl(-) into the cytosolic space from the basolateral space across the basolateral membrane by Cl(-) transporters, such as Na(+)-K(+)-2Cl(-) cotransporter (NKCC1, an isoform of NKCC), and (2) the releasing step of Cl(-) from the cytosolic space into the luminal (air) space across the apical membrane via Cl(-) channels, such as cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel. Transcellular Cl(-) secretion has been characterized by using various experimental techniques. For example, measurements of short-circuit currents in the Ussing chamber and patch clamp techniques provide us information on transepithelial ion movements via transcellular pathway, transepithelial conductance, activity (open probability) of single channel, and whole cell currents. Although many investigators have tried to clarify roles of Cl(-) channels and transporters located at the apical and basolateral membranes in transcellular Cl(-) secretion, it is still unclear how Cl(-) channels/transporters contribute to transcellular Cl(-) secretion and are regulated by various stimuli such as Ca(2+) and cAMP. In the present study, we simulate transcellular Cl(-) secretion using mathematical models combined with electrophysiological measurements, providing information on contribution of Cl(-) channels/transporters to transcellular Cl(-) secretion, activity of electro-neutral ion transporters and how Cl(-) channels/transporters are regulated.
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