ArticleFrontiers in aging neuroscience2015
Gray Matter Volume and Resting-State Functional Connectivity of the Motor Cortex-Cerebellum Network Reflect the Individual Variation in Masticatory Performance in Healthy Elderly People.
Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Parkinson's disease impairs masticatory function.Clinical oral investigations · 2017Trial
- Masticatory Dysfunction and Hippocampal Volume in Ageing Adults: An MRI-Based Scoping Review.Journal of oral rehabilitation · 2026Article
- Association between reduced chewing-induced brain blood flow and cognitive performance in mandibular prognathism patients in a pilot study.Scientific reports · 2026Article
- The Occlusal Contact Area Is Associated with the Magnitude but Not Peak Timing of Changes in Chewing-Induced Brain Blood Flow in Mandibular Prognathism.Dentistry journal · 2025Article
- Structural and functional MRI evidence for significant contribution of precentral gyrus to flexible oculomotor control: evidence from the antisaccade task.Brain structure & function · 2022Article
- Masticatory movements and food textures in older patients with eating difficulties.Gerodontology · 2022Article
- The Association between Age-Related Changes in Oral Neuromechanics and Alzheimer's Disease.Advances in geriatric medicine and research · 2021Article
- An fMRI Study of the Brain Network Involved in Teeth Tapping in Elderly Adults.Frontiers in aging neuroscience · 2020Article
- The relationship between masticatory ability, age, and dental and prosthodontic status in an institutionalized elderly dentate population in Qingdao, China.Clinical oral investigations · 2019Article
- Prefrontal Consolidation and Compensation as a Function of Wearing Denture in Partially Edentulous Elderly Patients.Frontiers in aging neuroscience · 2019Article
- Functional Adaptation of Oromotor Functions and Aging: A Focused Review of the Evidence From Brain Neuroimaging Research.Frontiers in aging neuroscience · 2019Review
- Revisiting the link between cognitive decline and masticatory dysfunction.BMC geriatrics · 2018Review
- Age-Related Difference in Functional Brain Connectivity of Mastication.Frontiers in aging neuroscience · 2017Article
- Widespread Volumetric Brain Changes following Tooth Loss in Female Mice.Frontiers in neuroanatomy · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroimaging studies have consistently identified brain activation in the motor area and the cerebellum during chewing. In this study, we further investigated the structural and functional brain signature associated with masticatory performance, which is a widely used index for evaluating overall masticatory function in the elderly. Twenty-five healthy elderly participants underwent oral examinations, masticatory performance tests, and behavioral assessments, including the Cognitive Abilities Screening Instrument and the short-form Geriatric Depression Scale. Masticatory performance was assessed with the validated colorimetric method, using color-changeable chewing gum. T1-weighted structural magnetic resonance imaging (MRI) and resting-state function MRI were performed. We analyzed alterations in gray matter volume (GMV) using voxel-based morphometry and resting-state functional connectivity (rsFC) between brain regions using the seed-based method. The structural and functional MRI analyses revealed the following findings: (1) the GMV change in the premotor cortex was positively correlated with masticatory performance. (2) The rsFC between the cerebellum and the premotor cortex was positively correlated with masticatory performance. (3) The GMV changes in the dorsolateral prefrontal cortex (DLPFC), as well as the rsFC between the cerebellum and the DLPFC, were positively correlated with masticatory performance. The findings showed that in the premotor cortex, a reduction of GMV and rsFC would reflect declined masticatory performance. The positive correlation between DLPFC connectivity and masticatory performance implies that masticatory ability is associated with cognitive function in the elderly. Our findings highlighted the role of the central nervous system in masticatory performance and increased our understanding of the structural and functional brain signature underlying individual variations in masticatory performance in the elderly.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.