Evidence map›Paper›PMID 26778962›Full record

ReviewFrontiers in cellular neuroscience2015

Current Challenges Facing the Translation of Brain Computer Interfaces from Preclinical Trials to Use in Human Patients.

Maxwell D Murphy, David J Guggenmos, David T Bundy, Randolph J Nudo

Abstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. The Evolution of Neuroprosthetic Interfaces.Critical reviews in biomedical engineering · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maxwell D MurphyBioengineering Graduate Program, University of KansasLawrence, KS, USA; Department of Rehabilitation Medicine, University of Kansas Medical CenterKansas City, KS, USA.
David J GuggenmosDepartment of Rehabilitation Medicine, University of Kansas Medical Center Kansas City, KS, USA.
David T BundyDepartment of Rehabilitation Medicine, University of Kansas Medical Center Kansas City, KS, USA.
Randolph J NudoDepartment of Rehabilitation Medicine, University of Kansas Medical CenterKansas City, KS, USA; Landon Center on Aging, University of Kansas Medical CenterKansas City, KS, USA.

Funding

REORGANIZATION OF MOTOR CORTEX FOLLOWING BRAIN INJURYR01NS030853 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI NUDO, RANDOLPH J. · 1993 to 2020
$6.5M
Kansas University Training Program in Neurological and Rehabilitation SciencesT32HD057850 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Jacob J. Sosnoff · 2009 to 2026
$3.4M
NICHD NIH HHS T32 HD057850NINDS NIH HHS R01 NS030853
6 · The paper itself

Abstract

Current research in brain computer interface (BCI) technology is advancing beyond preclinical studies, with trials beginning in human patients. To date, these trials have been carried out with several different types of recording interfaces. The success of these devices has varied widely, but different factors such as the level of invasiveness, timescale of recorded information, and ability to maintain stable functionality of the device over a long period of time all must be considered in addition to accuracy in decoding intent when assessing the most practical type of device moving forward. Here, we discuss various approaches to BCIs, distinguishing between devices focusing on control of operations extrinsic to the subject (e.g., prosthetic limbs, computer cursors) and those focusing on control of operations intrinsic to the brain (e.g., using stimulation or external feedback), including closed-loop or adaptive devices. In this discussion, we consider the current challenges facing the translation of various types of BCI technology to eventual human application.

Indexed as

brain-computer interface (BCI)closed-loop neuroprosthetic deviceselectrocorticography (ECoG)electroencephalography (EEG)microelectrodesneural prostheses

Identifiers

PMID26778962
PMCPMC4702293

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.