ReviewSeminars in cell & developmental biology2016
Pulling together: Tissue-generated forces that drive lumen morphogenesis.
Review in Seminars in cell & developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Tight junction structure, assembly and (dys)function.Nature reviews. Molecular cell biology · 2026Review
- Epithelial cell shape changes contribute to regulation of ureteric bud branching morphogenesis.The FEBS journal · 2025Article
- Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte- transdifferentiation.Cell & bioscience · 2025Article
- The maternal embrace: the protection of plant embryos.Journal of experimental botany · 2024Review
- Article
- Shaping epithelial lumina under pressure.Biochemical Society transactions · 2024Review
- In situ quantification of osmotic pressure within living embryonic tissues.Nature communications · 2023Article
- Topological morphogenesis of neuroepithelial organoids.Nature physics · 2023Article
- The cell cortex as mediator of pancreatic epithelial development and endocrine differentiation.Current opinion in genetics & development · 2022Review
- Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads.The Journal of cell biology · 2021Article
- Metabolic programming of nephron progenitor cell fate.Pediatric nephrology (Berlin, Germany) · 2021Review
- Programmed and self-organized flow of information during morphogenesis.Nature reviews. Molecular cell biology · 2021Review
- Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue.Nature communications · 2020Article
- Article
- Cellular crowding influences extrusion and proliferation to facilitate epithelial tissue repair.Molecular biology of the cell · 2019Article
- Article
- Adducins inhibit lung cancer cell migration through mechanisms involving regulation of cell-matrix adhesion and cadherin-11 expression.Biochimica et biophysica acta. Molecular cell research · 2019Article
- Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer's vesicle.eLife · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Mechanical interactions are essential for bending and shaping tissues during morphogenesis. A common feature of nearly all internal organs is the formation of a tubular network consisting of an epithelium that surrounds a central lumen. Lumen formation during organogenesis requires precisely coordinated mechanical and biochemical interactions. Whereas many genetic regulators of lumen formation have been identified, relatively little is known about the mechanical cues that drive lumen morphogenesis. Lumens can be shaped by a variety of physical behaviors including wrapping a sheet of cells around a hollow core, rearranging cells to expose a lumenal cavity, or elongating a tube via cell migration, though many of the details underlying these movements remain poorly understood. It is essential to define how forces generated by individual cells cooperate to produce the tissue-level forces that drive organogenesis. Transduction of mechanical forces relies on several conserved processes including the contraction of cytoskeletal networks or expansion of lumens through increased fluid pressure. The morphogenetic events that drive lumen formation serve as a model for similar mechanical processes occurring throughout development. To understand how lumenal networks arise, it will be essential to investigate how biochemical and mechanical processes integrate to generate complex structures from comparatively simple interactions.
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Registered trials
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