ArticleCNS neuroscience & therapeutics2016
Morphological Changes of Amygdala in Turner Syndrome Patients.
Article in CNS neuroscience & therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Effects of hypogonadism on brain development during adolescence in girls with Turner syndrome.Human brain mapping · 2019Article
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Authors and funding
8 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
aimsTurner's syndrome (TS) losts one of the X chromosomes and exhibits social cognition deficits. Previous studies have reported that women with TS demonstrated structural and functional abnormalities in brain, including increased volume in amygdala. However, most studies regarded the amygdala as a whole, and the abnormalities in the specific subregions of amygdala in TS have not been studied. Here, we aimed to investigate the local morphological changes of amygdala in TS using the surface morphology analysis method.
methodsA total of 19 adolescents with 45XO TS and 20 matched adolescents with typical development were evaluated using magnetic resonance imaging. The amygdalae of all participants were manually delineated. 3D surface remodeling and parameterization were performed based on the outlined boundaries of amygdalae. We extracted two surface metrics, namely direct Euclidean displacement and normal projection that were used to represent the morphology of amygdala.
resultsStatistical analysis showed significant outward deformation in the laterobasal subregion of left amygdala in patients with TS, compared with the controls using either direct Euclidean displacement or normal displacement.
conclusionsOur findings provide novel insight into the pathological changes in the amygdala of patients with TS.
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