ReviewExperimental physiology2016
The molecular actions of oestrogen in the regulation of vascular health.
Review in Experimental physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- The crucial role of hypertension in determining latent classes of metabolic syndrome in northern Iran and predictive power of these classes in non-alcoholic fatty liver: a gender-based insight.Frontiers in endocrinology · 2025Article
- Effects of Sex Hormones on Vascular Reactivity in Boys With Hypospadias.The Journal of clinical endocrinology and metabolism · 2024Article
- Chronic kidney disease promotes cerebral microhemorrhage formation.Journal of neuroinflammation · 2023Article
- Unruptured anterior Inferior cerebellar artery aneurysm following stereotactic irradiation for vestibular schwannoma: Case report and literature review.Frontiers in surgery · 2023Article
- Hyperuricemia and Endothelial Function: Is It a Simple Association or Do Gender Differences Play a Role in This Binomial?Biomedicines · 2022Review
- Bias in animal studies of estrogen effects on cardiovascular disease: A systematic review and meta-analysis.Research and practice in thrombosis and haemostasis · 2021Article
- Targeting the Endothelium to Achieve Cardioprotection.Frontiers in pharmacology · 2021Review
- Pathophysiological effects of androgens on the female vascular system.Biology of sex differences · 2020Review
- Oroxylin A Reduces Vasoconstriction in Rat Aortic Rings through Promoting NO Production and NOS Protein Expression via Estrogen Receptor Signal Pathway.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Follicle-stimulating hormone, but not cardiorespiratory fitness, is associated with flow-mediated dilation with advancing menopausal stage.Menopause (New York, N.Y.) · 2019Article
- Phytoestrogenic Effects of Blackcurrant Anthocyanins Increased Endothelial Nitric Oxide Synthase (eNOS) Expression in Human Endothelial Cells and Ovariectomized Rats.Molecules (Basel, Switzerland) · 2019Article
- Therapeutic management of hyperlipoproteinemia (a).Drugs in context · 2019Review
- Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan.American journal of physiology. Heart and circulatory physiology · 2018Review
- Episodic bouts of hyperaemia and shear stress improve arterial blood flow and endothelial function.European journal of applied physiology · 2018Article
- Age-, Gender-, andFrontiers in physiology · 2018Article
- Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1.Oncotarget · 2017Article
- Sex-specific eNOS activity and function in human endothelial cells.Scientific reports · 2017Article
- Resveratrol Treatment Normalizes the Endothelial Function and Blood Pressure in Ovariectomized Rats.Arquivos brasileiros de cardiologia · 2017Article
- The Body Guidelines: A Metacognitive and Harm Reducing Approach to Gender and Sex in Preclinical Medical School Curriculum.Journal of medical education and curricular developmentArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
NEW
findingsWhat is the topic of this review? This review summarizes the beneficial actions of oestrogen on the vasculature, highlighting both molecular mechanisms and functional outcomes. What advances does it highlight? The net effect of oestrogen on the vascular health of women continues to be debated. Recent advances have provided strong evidence for the role of membrane-bound oestrogen receptors in the maintenance of normal endothelial function. On a broader scale, functional outcomes of oestrogen actions on the vasculature may mediate the reduced risk of cardiovascular disease in premenopausal women. The conflicting implications of the large-scale clinical menopausal hormone therapy trials in humans versus the findings of studies on experimental animals underscore the limitations within our understanding of the molecular actions of oestrogen. However, recent research has provided improved insight into the actions of oestrogen on the endothelium and vascular smooth muscle. This review outlines the actions of oestrogen as it contributes to vascular structure, function and health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.