Evidence map›Paper›PMID 26778442›Full record

ArticleMagnetic resonance in medicine2017

In vivo, high-frequency three-dimensional cardiac MR elastography: Feasibility in normal volunteers.

Arvin Arani, Kevin L Glaser, Shivaram P Arunachalam, Phillip J Rossman, David S Lake, Joshua D Trzasko, Armando Manduca, Kiaran P McGee, Richard L Ehman, Philip A Araoz

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arvin AraniDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Kevin L GlaserDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Shivaram P ArunachalamDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Phillip J RossmanDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
David S LakeDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Joshua D TrzaskoDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Armando ManducaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Kiaran P McGeeDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Richard L EhmanDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Philip A AraozDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.

Funding

Magnetic Resonance ElastographyR37EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2016 to 2025
$4.0M
Magnetic Resonance ElastographyR01EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2003 to 2013
$3.1M
Cardiac Magnetic Resonance Elastography: Imaging Heart Failure PathophysiologyR01HL115144 · NHLBI · MAYO CLINIC ROCHESTER · PI ARAOZ, PHILIP ALEXANDER · 2012 to 2016
$2.0M
NHLBI NIH HHS R01 HL115144NIBIB NIH HHS R01 EB001981NIBIB NIH HHS R37 EB001981
6 · The paper itself

Abstract

purposeNoninvasive stiffness imaging techniques (elastography) can image myocardial tissue biomechanics in vivo. For cardiac MR elastography (MRE) techniques, the optimal vibration frequency for in vivo experiments is unknown. Furthermore, the accuracy of cardiac MRE has never been evaluated in a geometrically accurate phantom. Therefore, the purpose of this study was to determine the necessary driving frequency to obtain accurate three-dimensional (3D) cardiac MRE stiffness estimates in a geometrically accurate diastolic cardiac phantom and to determine the optimal vibration frequency that can be introduced in healthy volunteers.

methodsThe 3D cardiac MRE was performed on eight healthy volunteers using 80 Hz, 100 Hz, 140 Hz, 180 Hz, and 220 Hz vibration frequencies. These frequencies were tested in a geometrically accurate diastolic heart phantom and compared with dynamic mechanical analysis (DMA).

resultsThe 3D Cardiac MRE was shown to be feasible in volunteers at frequencies as high as 180 Hz. MRE and DMA agreed within 5% at frequencies greater than 180 Hz in the cardiac phantom. However, octahedral shear strain signal to noise ratios and myocardial coverage was shown to be highest at a frequency of 140 Hz across all subjects.

conclusionThis study motivates future evaluation of high-frequency 3D MRE in patient populations. Magn Reson Med 77:351-360, 2017. © 2016 Wiley Periodicals, Inc.

Indexed as

AdultCardiac Imaging TechniquesElasticity Imaging TechniquesFeasibility StudiesFemaleHeartHumansImaging, Three-DimensionalMagnetic Resonance ImagingModels, CardiovascularPhantoms, Imagingcardiac elastographycardiac MREmyocardial stiffness

Identifiers

PMID26778442
PMCPMC4947569

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.