ArticlePsychiatry research. Neuroimaging2016
Externalizing personality traits, empathy, and gray matter volume in healthy young drinkers.
Article in Psychiatry research. Neuroimaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis of associations between empathy and alcohol use and problems in clinical and non-clinical samples.Addiction (Abingdon, England) · 2022Pooled it
- Brain gray matter structures associated with trait impulsivity: A systematic review and voxel-based meta-analysis.Human brain mapping · 2021Pooled it
- Neural Correlates of Inhibitory Control in Impulsivity Traits in Non-Ecological Human-Computer Tasks: An ALE Meta-Analysis.Brain sciences · 2026Review
- Frequency and imaging correlates of neuropsychiatric symptoms in Progressive Supranuclear Palsy.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- The Indirect Effect of Prefrontal Gray Matter Volume on Suicide Attempts among Individuals with Major Depressive Disorder.Experimental neurobiology · 2022Article
- Translating preclinical models of alcohol seeking and consumption into the human laboratory using intravenous alcohol self-administration paradigms.Addiction biology · 2021Article
- Childhood assaultive trauma and physical aggression: Links with cortical thickness in prefrontal and occipital cortices.NeuroImage. Clinical · 2020Article
- Brain connectivity-informed regularization methods for regression.Statistics in biosciences · 2019Article
- Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers.Brain connectivity · 2018Article
- Cortical thickness and trait empathy in patients and people at high risk for alcohol use disorders.Psychopharmacology · 2017Article
- Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study.NeuroImage. Clinical · 2017Article
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7 authors.
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Abstract
Externalizing psychopathology has been linked to prefrontal abnormalities. While clinically diagnosed subjects show altered frontal gray matter, it is unknown if similar deficits relate to externalizing traits in non-clinical populations. We used voxel-based morphometry (VBM) to retrospectively analyze the cerebral gray matter volume of 176 young adult social to heavy drinkers (mean age=24.0±2.9, male=83.5%) from studies of alcoholism risk. We hypothesized that prefrontal gray matter volume and externalizing traits would be correlated. Externalizing personality trait components-Boredom Susceptibility-Impulsivity (BS/IMP) and Empathy/Low Antisocial Behaviors (EMP/LASB)-were tested for correlations with gray matter partial volume estimates (gmPVE). Significantly large clusters (pFWE<0.05, family-wise whole-brain corrected) of gmPVE correlated with EMP/LASB in dorsolateral and medial prefrontal regions, and in occipital cortex. BS/IMP did not correlate with gmPVE, but one scale of impulsivity (Eysenck I7) correlated positively with bilateral inferior frontal/orbitofrontal, and anterior insula gmPVE. In this large sample of community-dwelling young adults, antisocial behavior/low empathy corresponded with reduced prefrontal and occipital gray matter, while impulsivity correlated with increased inferior frontal and anterior insula cortical volume. These findings add to a literature indicating that externalizing personality features involve altered frontal architecture.
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