ArticlePsychiatry research. Neuroimaging2016
Prospective longitudinal study of subcortical brain volumes in individuals at high familial risk of mood disorders with or without subsequent onset of depression.
Article in Psychiatry research. Neuroimaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Cerebral lateral ventricular asymmetry: a meta-analysis and meta-regression of volumetric MRI studies.Neuroradiology · 2026Pooled it
- Prospective biomarkers of major depressive disorder: a systematic review and meta-analysis.Molecular psychiatry · 2020Pooled it
- Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies.Developmental cognitive neuroscience · 2019Pooled it
- Longitudinal Trajectory of Cognition, Brain Morphometry, and Brain Predicted Age in Unaffected First-Degree Relatives of Patients With Bipolar Disorder.Bipolar disorders · 2025Article
- A short-interval longitudinal study of associations between psychological distress and hippocampal grey matter in early adolescence.Brain imaging and behavior · 2024Article
- Persistence of amygdala hyperactivity to subliminal negative emotion processing in the long-term course of depression.Molecular psychiatry · 2024Article
- Associations Between Parental Mood and Anxiety Psychopathology and Offspring Brain Structure: A Scoping Review.Clinical child and family psychology review · 2022Article
- Longitudinal trajectories of brain age in young individuals at familial risk of mood disorder from the Scottish Bipolar Family Study.Wellcome open research · 2019Article
- Emerging depression in adolescence coincides with accelerated frontal cortical thinning.Journal of child psychology and psychiatry, and allied disciplines · 2018Article
- Risk for affective disorders is associated with greater prefrontal gray matter volumes: A prospective longitudinal study.NeuroImage. Clinical · 2018Article
- Stability of Cortical Thinning in Persons at Increased Familial Risk for Major Depressive Disorder Across 8 Years.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Subcortical volumetric brain abnormalities have been observed in mood disorders. However, it is unknown whether these reflect adverse effects predisposing to mood disorders or emerge at illness onset. Magnetic resonance imaging was conducted at baseline and after two years in 111 initially unaffected young adults at increased risk of mood disorders because of a close family history of bipolar disorder and 93 healthy controls (HC). During the follow-up, 20 high-risk subjects developed major depressive disorder (HR-MDD), with the others remaining well (HR-well). Volumes of the lateral ventricles, caudate, putamen, pallidum, thalamus, hippocampus and amygdala were extracted for each hemisphere. Using linear mixed-effects models, differences and longitudinal changes in subcortical volumes were investigated between groups (HC, HR-MDD, HR-well). There were no significant differences for any subcortical volume between groups controlling for multiple testing. Additionally, no significant differences emerged between groups over time. Our results indicate that volumetric subcortical brain abnormalities of these regions using the current method appear not to form familial trait markers for vulnerability to mood disorders in close relatives of bipolar disorder patients over the two-year time period studied. Moreover, they do not appear to reduce in response to illness onset at least for the time period studied.
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Registered trials
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