Evidence map›Paper›PMID 26778189›Full record

ReviewTrends in molecular medicine2016

The Changing Landscape of Renal Inflammation.

Thomas Ernandez, Tanya Norton Mayadas

Registry-linked trialAbstract readReview
In one paragraph

Review in Trends in molecular medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04238338 (Association of Monocyte / Lymphocyte Ratio With Risk of Death and Cardiovascular Events in Peritoneal Dialysis Patients), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04238338 unknown statusnot on this mapstarted 2020, after this paper: background citation

Association of Monocyte / Lymphocyte Ratio With Risk of Death and Cardiovascular Events in Peritoneal Dialysis Patients

TypeobservationalSponsorZhujiang HospitalRan2020 to 2022Enrolled266ConditionsPeritoneal Dialysis, InflammationArmsmonocyte / lymphocyte ratio
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
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  15. MicroRNAs in shaping the resolution phase of inflammation.Seminars in cell & developmental biology · 2022
    Review
  16. Mired in the glomeruli: witnessing live neutrophil recruitment in the kidney.American journal of physiology. Cell physiology · 2021
    Review
  17. The mScience immunology · 2021
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Thomas ErnandezService of Nephrology, Department of Medical Specialties, University Hospital of Geneva, Geneva, Switzerland.
Tanya Norton MayadasDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: tmayadas@rics.bwh.harvard.edu.
Harvard University · USUniversity Hospital of Geneva · CH

Funding

Regulators of Immune Complex Mediated Neutrophil Recruitment and Tissue InjuryR01HL065095 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MAYADAS, TANYA N · 1999 to 2025
$11.9M
TNFR2 Regulation of Leukocyte Recruitment in GlomerulonephritisR01DK099507 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI MAYADAS, TANYA N · 2014 to 2018
$2.1M
NHLBI NIH HHS R01 HL065095NIDDK NIH HHS R01 DK099507
6 · The paper itself

Abstract

Kidney inflammation is a major contributor to progressive renal injury, leading to glomerulonephritis (GN) and chronic kidney disease. We review recent advances in our understanding of leukocyte accumulation in the kidney, emphasizing key chemokines involved in GN. We discuss features of renal inflammation such as the evolving concept of immune cell plasticity. We also describe certain aspects of organ-specific tissue microenvironments in shaping immune cell responses, as well as the current knowledge of how regulatory T lymphocytes impact on other immune effector cell populations to control inflammation. It is clear that present and future research in these areas may contribute to the development of novel targeted therapeutics, with the hope of alleviating the burden of end-stage renal disease (ESRD).

Indexed as

Cell MovementCellular MicroenvironmentCytokinesGene Expression RegulationGlomerulonephritisHumansImmunity, InnateImmunologic FactorsInflammationKidneyKidney Failure, ChronicRenal Insufficiency, ChronicSignal TransductionTh1 CellsT-Lymphocytes, RegulatoryCytokinesImmunologic Factorschemokineseffector immune cellsenvironmental triggersglomerulusleukocyte recruitmentlocal inflammationphenotype stabilityregulatory immune cells

Identifiers

PMID26778189
PMCPMC4738004
OpenAlexW2229394180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.